{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:17:46Z","timestamp":1781759866421,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG068338"],"award-info":[{"award-number":["R01AG068338"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072931"],"award-info":[{"award-number":["P30AG072931"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz & Dem Diag Ass & Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n The National Insitutes of Health Toolbox (NIHTB) measures may be useful for Alzheimer's disease (AD) risk detection. This study investigates whether cognitively normal older adults with and without elevated brain amyloid, an early AD biomarker, differed on NIHTB cognitive and motor subtests and whether inclusion of pTau\u2010217 enhanced this differentiation. Motor measures were of interest based on past research reporting linkages to early AD pathology.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Data from 112 consensus\u2010diagnosed cognitively normal older adults who completed amyloid\u2010PET imaging, blood draw for pTau217 analysis, and NIHTB Cognition and Motor batteries were analyzed using linear regression.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Amyloid positivity significantly predicted performance on only NIHTB Standing Balance (\n F<\/jats:italic>\n (2,86)\u00a0=\u00a09.90,\n p\u00a0<\/jats:italic>\n <\u00a00.001). Inclusion of pTau217 enhanced prediction of Standing Balance (\n F<\/jats:italic>\n (4,84)\u00a0=\u00a05.88,\n p\u00a0<\/jats:italic>\n <\u00a00.001) and Walking Endurance (\n F<\/jats:italic>\n (4,88)\u00a0=\u00a09.70,\n p\u00a0<\/jats:italic>\n <\u00a00.001) and Dominant\u2010hand Grip Strength (\n F<\/jats:italic>\n (2,92)\u00a0=\u00a051.59,\n p\u00a0<\/jats:italic>\n <\u00a00.001).\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n For AD\u2010related detection research, findings support inclusion of NIHTB motor measures, which may prove more sensitive early in the disease course before overt cognitive change.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n The National Institutes of Health ToolBox motor performance may signal early Alzheimer's disease (AD) risk, even before memory change.<\/jats:p>\n <\/jats:list-item>\n \n Balance performance may be sensitive to early cumulative AD\u2010neuropathology loading.<\/jats:p>\n <\/jats:list-item>\n \n Motor measures should be included in early AD\u2010risk detection batteries.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dad2.70237","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:57:30Z","timestamp":1767855450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Motor, not cognitive, performance relates to amyloid status in normal older adults"],"prefix":"10.1002","volume":"18","author":[{"given":"Amanda","family":"Cook Maher","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly N.","family":"DuBois","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience College of Human Medicine Michigan State University Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Kanaan","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience College of Human Medicine Michigan State University Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Koeppe","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Bross","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan Ann Arbor Michigan 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