{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:01:59Z","timestamp":1781092919021,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100003077","name":"Knowledge Foundation","doi-asserted-by":"publisher","award":["20210002"],"award-info":[{"award-number":["20210002"]}],"id":[{"id":"10.13039\/100003077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cardiorespiratory fitness (CRF) is linked to dementia risk, but moderating factors remain unclear. This study examined how and when CRF in adulthood is associated with late\u2010onset dementia (&gt; 65 years) and whether sex, civil status, or education moderate this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a cohort of 370,980 dementia\u2010free individuals followed for a mean of 11.9 (standard deviation 6.0) years, CRF was estimated via a submaximal cycle test, with dementia incidence obtained from Swedish National Healthcare Registries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Results showed that high CRF was associated with lower dementia risk in those under age 55 (hazard ratio [HR]: 0.58, 95% confidence interval [CI] 0.36\u20130.92) and those &gt; 55 (HR: 0.75, 95% CI 0.63\u20130.89) at CRF assessment. Medium education levels moderate the association in individuals &lt; 55 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings underscore the role of maintaining a high CRF in dementia prevention, emphasizing education level as a critical moderating factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>High cardiorespiratory fitness (CRF) is longitudinally associated with a lower risk of late\u2010onset dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The association was evident in those both under and over age 55 at CRF assessment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher education levels moderated the relationship in those &lt; 55 years.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sex and civil status did not moderate the association.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70239","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T03:00:03Z","timestamp":1770606003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mid\u2010life cardiorespiratory fitness and risk of late\u2010onset dementia incidence"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-1956","authenticated-orcid":false,"given":"Camilla A.","family":"Wiklund","sequence":"first","affiliation":[{"name":"Department of Physical Activity and Health The Swedish School of Sport and Health Sciences  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physical Activity and Health The Swedish School of Sport and Health Sciences  Stockholm Sweden"},{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Lindwall","sequence":"additional","affiliation":[{"name":"Department 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