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We evaluated differences in demographics, apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) status, biomarkers, and cognition among older adults with concordant and discordant visual\u2010quantitative A\u03b2\u2010PET. Discordance was defined as positive visual read (V) of A\u03b2\u2010PET with below\u2010threshold Centiloid quantification (Q; CL\u00a0&lt;25; V+\/Q\u2013) or negative visual read with CL\u00a0\u226525 (V\u2013\/Q+).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We studied 386 participants (mean age \u00b1 SD: 70.7\u00a0\u00b1\u00a07.8, 55.2% female, 44.6% Hispanic White). Compared to V+\/Q\u2013, V\u2013\/Q+ had a higher frequency of\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers (40%). Black\/African American participants were overrepresented in V\u2013\/Q+ (40.9%). Both discordant groups had higher\u00a0plasma phosphorylated tau 217\u00a0(p\u2010tau217) and glial fibrillary acidic protein (GFAP) than V\u2013\/Q\u2013 but lower than V+\/Q+. Discordant groups had greater gray matter volume and better cognitive performance than V+\/Q+.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Discordant A\u03b2\u2010PET findings likely hold clinical significance and may reflect early stages of neuropathological progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Groups with concordant\/discordant visual\u2010quantitative amyloid beta\u2013positron emission tomography (A\u03b2\u2010PET) results were compared.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Visual\u2013\/quant+ were more likely than visual+\/quant\u2013 to be apolipoprotein E (\n                            <jats:italic>APOE<\/jats:italic>\n                            ) \u03b54 carriers and Black\/African American.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Discordant groups had higher plasma phosphorylated tau 217 (p\u2010tau217) and glial fibrillary acidic protein (GFAP) than concordant negative.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Discordant groups had less atrophy and better cognition than concordant positive.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Centiloid quantification should supplement visual reads in clinical settings.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70241","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:23:24Z","timestamp":1768472604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors associated with discordant visual and quantitative amyloid PET results"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-8306","authenticated-orcid":false,"given":"Jasmin E","family":"Guevara","sequence":"first","affiliation":[{"name":"Department of Clinical and Health Psychology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily F","family":"Matusz","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology University of Florida  Gainesville Florida 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