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Amyloid status (A\u03b2+ or A\u03b2\u2212) was determined by amyloid positron emission tomography (PET) scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among participants, 24.8% were A\u03b2+. In the cognitively unimpaired (CDR\u2010GS 0) group, A\u03b2+ individuals reported slightly greater self\u2010perceived cognitive concerns (Cognitive Function Instrument [CFI\u2010self]). For those with mild impairment (CDR\u2010GS 0.5), A\u03b2+ status was associated with worse clinical scores, greater cognitive complaints, more depressive symptoms, and poorer memory and global cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings align with major Western studies, emphasizing that CFI\u2010self is a valuable tool for identifying early AD pathology across diverse populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Comparing characteristics by amyloid status in Japanese non\u2010demented older adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Positron emission tomography\u2013positive (PET+) scans in cognitively unimpaired individuals were associated with Cognitive Function Instrument\u2013negative (CFI\u2010) participants.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>PET+ in mild cognitive impairment (MCI) was linked to functional, cognitive, and affective decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CFI\u2010 participants will aid early Alzheimer's pathology detection in diverse groups.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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University of Tokyo  Bunkyo\u2010ku Tokyo Japan"},{"name":"Dementia Inclusion and Therapeutics The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-8167","authenticated-orcid":false,"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Dementia Inclusion and Therapeutics The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics Brain Research Institute Niigata University  Niigata\u2010shi Niigata 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