{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:56:58Z","timestamp":1790081818866,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz & Dem Diag Ass & Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Antipsychotic medication (APM) use in nursing home (NH) patients with dementia is common but carries risks. This study assessed the association between APM use and mortality, stroke, and myocardial infarction (MI) compared to non\u2010use, as well as differences between first\u2010 and second\u2010generation APMs.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A serial cross\u2010sectional study using Medicare data examined outcomes from 2012 to 2015 in a national sample of 328,138 US NH residents aged 50 and older with dementia. Multivariate logistic regressions were used to analyze risk.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n APM use was associated with increased mortality in all years (odds ratio [OR] range: 2.39 to 1.23, all\n p\u00a0<\/jats:italic>\n <\u00a00.001) and stroke risk from 2012 to 2014 (OR range: 1.17 to 1.10,\n p\u00a0<\/jats:italic>\n <\u00a00.01) but not MI. First\u2010generation APMs posed a higher mortality risk than second\u2010generation APMs, with no significant stroke or MI differences.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Findings highlight the need for cautious APM use in dementia patients in NHs due to elevated mortality and stroke risks.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Study provides insights into APM risks in underrepresented nursing home (NH) dementia population.<\/jats:p>\n <\/jats:list-item>\n \n APM use in NH dementia patients is linked to higher death risk.<\/jats:p>\n <\/jats:list-item>\n \n First\u2010generation APMs showed higher mortality risk than second\u2010generation APMs.<\/jats:p>\n <\/jats:list-item>\n \n Overall, APM use is associated with increased stroke risk.<\/jats:p>\n <\/jats:list-item>\n \n No association was found between APM use and MI risk overall.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dad2.70247","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:13:06Z","timestamp":1768284786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of antipsychotic medication use and type on mortality and cardiovascular risks in nursing home patients with dementia"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3684-5357","authenticated-orcid":false,"given":"Hamid R.","family":"Okhravi","sequence":"first","affiliation":[{"name":"Glennan Center for Geriatrics and Gerontology Lawrence J. Goldrich Institute for Integrated NeuroHealth Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medicine Research and Infrastructure Service Enterprise (RISE) Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Sentara Medical Group Neurology Division Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brynn E.","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Research & Infrastructure Service Enterprise (RISE) Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"issue":"38","key":"e_1_2_8_2_1","first-page":"1","article-title":"Long\u2010term care providers and services users in the United States: data from the national study of long\u2010term care providers, 2013\u20132014","volume":"3","author":"Harris\u2010Kojetin L","year":"2016","journal-title":"Vital Health Stat"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1858"},{"key":"e_1_2_8_4_1","volume-title":"Public Health Advisory: Deaths with Antipsychotics in Elderly Patients with Behavioral Disturbances","author":"US Food and Drug Administration"},{"key":"e_1_2_8_5_1","volume-title":"Information for Healthcare Professionals: Conventional Antipsychotics","author":"US Food and Drug Administration"},{"key":"e_1_2_8_6_1","volume-title":"House Report 118\u2010124","author":"U.S. Congress"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610205002243"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31802d0b00"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04597yel"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e977"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11030347"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.3018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10303"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010021\u201001790\u20107"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31819b8936"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14111"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.01.016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010019\u20102176\u20103"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e31815a2531"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2347"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2011.03479.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061771"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.28"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13\u20102796"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v66n0901"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490797"},{"key":"e_1_2_8_27_1","volume-title":"National Partnership to Improve Dementia Care in Nursing Homes","author":"Centers for Medicare & Medicaid Services"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2024.105463"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2025.24.1.24"},{"key":"e_1_2_8_30_1","unstructured":"Centers for Medicare and Medicaid Services. 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