{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:31:56Z","timestamp":1787610716905,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020044","name":"Yale School of Public Health, Yale University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020044","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011493","name":"Whitney and Betty MacMillan Center for International and Area Studies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study aimed to compare the willingness to use Alzheimer's disease (AD) predictive\u2013diagnostic procedures between Mapuche (Indigenous) and non\u2010Indigenous older adults in Chile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We conducted a cross\u2010sectional study including Mapuche (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0167) and non\u2010Indigenous (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0248) older adults. Willingness to undergo five predictive\u2013diagnostic procedures (AD risk test, neuropsychological assessment, blood test, brain imaging, and cerebrospinal fluid analysis) was evaluated. Logistic regression models were used to identify factors associated with willingness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Overall willingness was high, except for cerebrospinal fluid testing (39.1%). In fully adjusted models, Mapuche participants were significantly less willing to undergo neuropsychological assessment (77.8%\u00a0vs. 92.3%), blood testing (68.3%\u00a0vs. 89.9%), and brain imaging (73.1%\u00a0vs. 84.3%). Key determinants of willingness varied by ethnic group and included age, sex, AD\u2010related worry, social determinants, and number of dementia risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Despite high overall willingness, ethnic identity and psychosocial factors significantly influenced receptiveness to AD predictive\u2013diagnostic procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Indigenous populations in high\u2010income countries face a higher risk of dementia, making Alzheimer's disease (AD) biomarker and diagnostic research a critical priority in these groups.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Despite this, Indigenous and Latin American populations remain among the most underrepresented in dementia research.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In a sample of Indigenous (Mapuche) and non\u2010Indigenous older adults in Chile, most participants reported willingness to use AD biomarkers and diagnostic procedures.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In fully adjusted models, Mapuche individuals were significantly less willing to undergo neuropsychological testing, blood tests, and brain imaging for AD risk prediction.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Willingness to use AD biomarkers varied by ethnic identity and was influenced by age, social determinants, and attitudes toward AD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70261","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:17:48Z","timestamp":1769602668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Willing, but unequally: Indigenous identity influences participation in Alzheimer's disease biomarker research in Chile"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5844-8700","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Aravena","sequence":"first","affiliation":[{"name":"Department of Social &amp; Behavioral Sciences School of Public Health Yale University  New Haven Connecticut USA"},{"name":"Unidad de Nutrici\u00f3n P\u00fablica Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Saguez","sequence":"additional","affiliation":[{"name":"Unidad de Nutrici\u00f3n P\u00fablica Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s H.","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Unidad de Nutrici\u00f3n P\u00fablica Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Herrera","sequence":"additional","affiliation":[{"name":"Hospital Hernan Henriquez Aravena  Temuco 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