{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:34:38Z","timestamp":1787506478504,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease manifests differently across ancestral groups, with African populations showing distinct fluid biomarker levels, neuroimaging patterns, and\n                    <jats:italic>post mortem<\/jats:italic>\n                    pathology. These differences may compromise diagnostic accuracy and exacerbate health disparities. This systematic review, examined studies published from 2015 to 2025 assessing amyloid\u2010\u03b2 and tau via fluid assays and neuroimaging. Findings reveal ancestry\u2010linked variation where African populations exhibit lower cerebrospinal fluid\/plasma A\u03b242\/A\u03b240 and p\u2010tau181 ratios, with neuroimaging showing broadly similar reduced positron emission tomography patterns but slightly elevated amyloid and reduced tau signals. Limited\n                    <jats:italic>post mortem<\/jats:italic>\n                    data suggest reduced plaque and tangle densities despite comparable dementia severity. Genetic, environmental, and sociocultural factors contribute to these disparities. Diagnostic thresholds derived from non\u2010African cohorts risk underdiagnosing AD in African individuals. There is an urgent need to recalibrate and validate biomarker protocols to ensure equitable and accurate dementia diagnosis across diverse populations.\n                  <\/jats:p>","DOI":"10.1002\/dad2.70263","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T03:01:32Z","timestamp":1770606092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Population disparities in Alzheimer's disease: A systematic review of fluid and neuroimaging biomarkers"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4045-1364","authenticated-orcid":false,"given":"Linus","family":"Kpelle","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science School of Allied Health Sciences University of Cape Coast  Cape Coast 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