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Its performance in underrepresented racial\/ethnic groups remains insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 2798 participants from the Health and Aging Brain Study\u2013Health Disparities, including non\u2010Hispanic White, non\u2010Hispanic Black, and Hispanic adults. Multivariable logistic regression and receiver operating characteristic analyses assessed associations and discriminative accuracy between plasma p\u2010tau217 and clinical cognitive impairment with racial\/ethnic\u2010specific thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Across all groups, p\u2010tau217 levels were higher in cognitively impaired than unimpaired participants. Elevated p\u2010tau217 was associated with greater odds of cognitive impairment in all racial and ethnic groups. Discriminative accuracy was modest but significant (area under the curve 0.65\u20130.72), with highest performance in non\u2010Hispanic Black and lowest in Hispanic participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 is robustly associated with cognitive impairment across diverse populations with varying thresholds, highlighting the need for population\u2010specific calibration to support equitable biomarker implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70269","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:15:51Z","timestamp":1773015351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma p\u2010tau217 and cognitive impairment: Evaluating biomarker equity across racial\/ethnic groups in HABS\u2010HD"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-9456","authenticated-orcid":false,"given":"Cellas A.","family":"Hayes","sequence":"first","affiliation":[{"name":"School of Medicine Department of Epidemiology and Population Health Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Najmi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of California Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-3641","authenticated-orcid":false,"given":"Joey Annette","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Alzheimer's Disease Cooperative Study University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8450-7352","authenticated-orcid":false,"given":"Anhiti","family":"Dharmapuri","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Healthy Brain Aging Sleep Center NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-9252","authenticated-orcid":false,"given":"Charisse N.","family":"Winston","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Keck School of Medicine of the University of Southern California, Alzheimer's Therapeutic Research Institute \u2010 Neuroscience Translational Research Division  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"*The Health and Aging Brain Study (HABS\u2010HD) Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081836"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000977\u20105"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae346"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021173"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200861"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105405"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70565"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13525"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100092"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3444"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12433"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12134"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4471"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70164"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12202"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70140"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251365128"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70045"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12668"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010215620"},{"key":"e_1_2_8_25_1","unstructured":"G. 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