{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:51:21Z","timestamp":1787957481308,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Variables predicting Alzheimer's disease (AD) are not limited to individual\u2010level risk factors. The purpose of this investigation is to assess multilevel predictors of AD prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>US county\u2010level datasets incorporating 45 predictor variables were analyzed cross\u2010sectionally using artificial intelligence analytical methods. A Light Gradient\u2010Boosting Machine model was trained to predict county\u2010level AD after which model performance and feature importance were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The final model retained 20 features and explained 75% (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.75) of the variance in AD prevalence. Racial and ethnic minority status showed the highest importance value (0.848), far exceeding all other features (e.g., poor sleep ranked second with importance value of 0.153).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This study confirmed upstream factors as being significant predictors of AD prevalence and racial and ethnic minority status as being the most important. From a policy perspective, efforts to reduce population levels of AD prevalence should consider addressing racial and ethnic disparities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70274","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:25:41Z","timestamp":1771316741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multilevel prediction of Alzheimer's disease dementia in the United States: An artificial intelligence analysis"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-6733","authenticated-orcid":false,"given":"Nicolaas P.","family":"Pronk","sequence":"first","affiliation":[{"name":"HealthPartners Institute  Minneapolis Minnesota USA"},{"name":"Department of Health Policy and Management University of Minnesota  Minneapolis Minnesota USA"},{"name":"Healthy Living for Pandemic Event Protection (HL \u2013 PIVOT) Network  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Healthy Living for Pandemic Event Protection (HL \u2013 PIVOT) Network  Chicago Illinois USA"},{"name":"Department of Physical Therapy College of Applied Science University of Illinois  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Woodard","sequence":"additional","affiliation":[{"name":"HealthPartners Institute  Minneapolis Minnesota USA"},{"name":"Nationhood Lab, Pell Center for International Relations and Public Policy Salve Regina University  Newport Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Healthy Living for Pandemic Event Protection (HL \u2013 PIVOT) Network  Chicago Illinois USA"},{"name":"Department of Physical Therapy College of Applied Science University of Illinois  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Arena","sequence":"additional","affiliation":[{"name":"HealthPartners Institute  Minneapolis Minnesota USA"},{"name":"Healthy Living for Pandemic Event Protection (HL \u2013 PIVOT) Network  Chicago Illinois USA"},{"name":"Department of Physical Therapy College of Applied Science University of Illinois  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.08.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.5.742"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30499\u2010X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.17"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3063"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13081"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.12923"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab083"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14387"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13027"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2025.03.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2025.03.013"},{"key":"e_1_2_10_16_1","unstructured":"WoodardC.American Nations: a History of the Eleven Rival Regional Cultures of North America.2011. 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