{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:01:55Z","timestamp":1781092915396,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG084134"],"award-info":[{"award-number":["AG084134"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz & Dem Diag Ass & Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n Plasma phosphorylated tau (p\u2010tau)217 levels and apolipoprotein E (\n APOE<\/jats:italic>\n ) \u03b54 genotype are used for prodromal identification of individuals at high risk for dementia. We used baseline samples from cognitively normal subjects in the Risk Reduction for Alzheimer's Disease (rrAD) clinical trial (NCT02913664) to investigate the relationship between these two markers in older adults with additional vascular risk factors.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We measured\n APOE<\/jats:italic>\n genotype, plasma p\u2010tau217, and standard neuroimaging metrics in 400 rrAD participants, aged 60 to 84 years, with sedentary lifestyle, hypertension, and hypercholesterolemia.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Plasma p\u2010tau217 was 57% higher in subjects with at least one\n APOE<\/jats:italic>\n \u03b54 allele, increased with age, was higher in males, and negatively correlated with brain volume measures by magnetic resonance imaging.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n Plasma p\u2010tau217 demonstrated elevation in the\n APOE<\/jats:italic>\n \u03b54 genotype in cognitively normal older adults. These data also suggest that brain volume shrinkage in males is related to elevated p\u2010tau217.\n APOE<\/jats:italic>\n genotyping will be important for clinical practice using p\u2010tau217 quantification.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dad2.70279","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:04:52Z","timestamp":1773039892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma p\u2010tau217 and\n APOE<\/i>\n genotype: Prodromal Alzheimer's disease staging"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-4429","authenticated-orcid":false,"given":"Ann M.","family":"Stowe","sequence":"first","affiliation":[{"name":"Department of Neurology University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Cortez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"Hynan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Cantrell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Raman","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Vidoni","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center University of Kansas Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Binder","sequence":"additional","affiliation":[{"name":"Division of General Medicine and Geriatrics Washington University St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Burns","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center University of Kansas Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Keller","sequence":"additional","affiliation":[{"name":"Institute for Dementia Research & Prevention Pennington Biomedical Research Center Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana R.","family":"Kerwin","sequence":"additional","affiliation":[{"name":"Kerwin Medical Center and Chief of Geriatrics Texas Health Presbyterian Hospital Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristyn","family":"Hall","sequence":"additional","affiliation":[{"name":"Texas Health Presbyterian Hospital Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Yanev","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanpen","family":"Vongpatanasin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Gruss Magnetic Resonance Research Center Albert Einstein College of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Scheel","sequence":"additional","affiliation":[{"name":"Department of Radiology Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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