{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:00:46Z","timestamp":1781092846088,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Evidence suggests that autonomic symptoms in frontotemporal dementia (FTD) may relate to hypothalamic pathology. We investigated (1) autonomic symptoms in FTD, primary psychiatric disorders (PPD), and controls; (2) hypothalamic volumes; and (3) their associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Autonomic Symptoms Questionnaire (ASQ) data were collected from FTD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031), PPD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030), and controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030). MRI data from these and additional participants (FTD\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0259, PPD\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a044, controls\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a062) were analyzed using a deep learning approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      FTD and PPD groups reported more cardiovascular symptoms than controls (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.020;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.049). FTD patients showed greater thermodysregulation (vs. PPD\n                      <jats:italic>p<\/jats:italic>\n                      = 0.026; vs. controls\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012) and altered pain perception (FTD 13%, PPD 2%, controls 1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). FTD showed smaller hypothalamic subregions, except the left inferior\u2010tubular area. In FTD, autonomic symptoms correlated with subregional hypothalamic volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>FTD patients exhibit increased autonomic symptoms across several domains compared to PPD and controls; moreover, FTD is associated with smaller regional hypothalamic volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70284","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:44:17Z","timestamp":1773006257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autonomic dysfunction and hypothalamic atrophy in frontotemporal dementia and primary psychiatric disorders"],"prefix":"10.1002","volume":"18","author":[{"given":"Yannick S. S.","family":"Timar","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Department of Neurology Medisch Spectrum Twente  Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule Emilie","family":"van Engelen","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"},{"name":"GGZ inGeest Specialized Mental Health Care, Location De Nieuwe Valerius  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Venkatraghavan","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Amsterdam UMC Vrije Universiteit  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Billot","sequence":"additional","affiliation":[{"name":"Inria, Universit\u00e9 C\u00f4te d'Azur, Epione team, Sophia\u2010Antipolis  Valbonne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay Lydia Petronella","family":"Fieldhouse","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochum J.","family":"van't Hooft","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterre C. M.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris S.","family":"Koevoets","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc W.","family":"Hartog","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Groot","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Amsterdam UMC Vrije Universiteit  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mardien L.","family":"Oudega","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration, Alzheimer Center Amsterdam, Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Department of Psychiatry Amsterdam UMC location Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Mood Anxiety Psychosis Sleep &amp; Stress Program  Amsterdam Noord\u2010Holland he Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jort (Everard) G. 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