{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:25:12Z","timestamp":1787498712647,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007364","name":"Fondazione CRT","doi-asserted-by":"publisher","award":["(105128\/2023.0366)"],"award-info":[{"award-number":["(105128\/2023.0366)"]}],"id":[{"id":"10.13039\/100007364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma phosphorylated tau at threonine 217 (p\u2010tau217) has shown excellent diagnostic performance for Alzheimer's disease (AD), yet real\u2010world validation and implementation pathways remain limited. This study assessed its clinical applicability and proposed a practical workflow for memory clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217, p\u2010tau181, and neurofilament light chain (NfL) were quantified in consecutive patients referred for cognitive assessment. Cerebrospinal fluid (CSF) amyloid beta (A\u03b2) 42\/40 defined amyloid (A) status, and final etiological diagnoses were reached through multidisciplinary consensus integrating clinical, neuropsychological, and metabolic imaging data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 163 patients (mean age 69.3\u00a0\u00b1\u00a07.4 years, 52% female), plasma p\u2010tau217 distinguished A+ from A\u2212 individuals (area under the curve [AUC] 0.90, 81% sensitivity, 91% specificity). AD patients showed the highest p\u2010tau217 levels, while non\u2010AD neurodegenerative disorders exhibited elevated NfL (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). A dual cut\u2010off strategy with 95% sensitivity and specificity could have avoided 65% of lumbar punctures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 demonstrated robust clinical validity and supports structured integration into routine diagnostic pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70286","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:51:05Z","timestamp":1773013865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasma p\u2010tau217 for Alzheimer's disease diagnosis: a memory clinic implementation approach"],"prefix":"10.1002","volume":"18","author":[{"given":"Giorgia","family":"Brodini","sequence":"first","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi\u2010Montalcini\u201d University of Turin  Turin Italy"},{"name":"Center for Cognitive Disorders and Dementias Department of Neuroscience and Mental Health AOU Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-3632","authenticated-orcid":false,"given":"Fausto","family":"Roveta","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi\u2010Montalcini\u201d University of Turin  Turin Italy"},{"name":"Center for Cognitive Disorders and Dementias Department of Neuroscience and Mental Health AOU Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Mario","family":"Chiarandon","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi\u2010Montalcini\u201d University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Boschi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi\u2010Montalcini\u201d University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Bonino","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi\u2010Montalcini\u201d University of Turin  Turin Italy"},{"name":"Center for Cognitive Disorders and Dementias Department of Neuroscience and Mental Health AOU Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Maria","family":"Piella","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi\u2010Montalcini\u201d University of Turin  Turin Italy"},{"name":"Center for Cognitive Disorders and Dementias Department of Neuroscience and Mental Health AOU Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Cermelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi\u2010Montalcini\u201d University of Turin  Turin Italy"},{"name":"Center for Cognitive Disorders and Dementias Department of Neuroscience and Mental Health AOU Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Limoncelli","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Clinical Biochemistry laboratory \u201cBaldi e Riberi\u201d A.O.U. 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