{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:01:21Z","timestamp":1781092881842,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study examined whether performance on the web\u2010based Latin American Spanish Face\u2013Name Associative Memory Exam (LAS\u2010FNAME), an associative memory test, is associated with plasma biomarkers in autosomal dominant Alzheimer's disease (ADAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      One hundred sixty\u2010one members from the Colombian kindred with presenilin\u20101 (\n                      <jats:italic>PSEN1<\/jats:italic>\n                      ) E280A mutation (61 cognitively unimpaired carriers, 22 cognitively impaired carriers, and 78 non\u2010carriers), completed the web\u2010based LAS\u2010FNAME and provided blood samples for biomarker analysis. Analysis of covariance was used to compare LAS\u2010FNAME performance among groups and Spearman correlations to examine its associations with levels of plasma phosphorylated tau (p\u2010tau)217, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Carriers had lower LAS\u2010FNAME performance (P\u00a0&lt;\u00a00.001) and higher p\u2010tau217 (P\u00a0&lt;\u00a00.001), NfL (P\u00a0=\u00a00.013), and GFAP (P\u00a0&lt;\u00a00.001) levels than non\u2010carriers. Higher p\u2010tau217, NfL, and GFAP were associated with worse LAS\u2010FNAME performance, controlling for age, sex, and education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The web\u2010based LAS\u2010FNAME is a promising tool for detecting early memory decline in AD, warranting future studies to evaluate its longitudinal utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            The web\u2010based Latin American Spanish Face\u2013Name Associative Memory Exam (LAS\u2010FNAME) detects memory decline in presenilin 1 (\n                            <jats:italic>PSEN1<\/jats:italic>\n                            ) mutation carriers.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            LAS\u2010FNAME scores correlate with blood biomarkers in\n                            <jats:italic>PSEN1<\/jats:italic>\n                            carriers.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The web\u2010based format enables remote assessment via participants\u2019 personal devices.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The study was conducted in Spanish\u2010speaking adults at risk for dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings support combined use of digital cognitive tools and blood biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70289","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T02:59:04Z","timestamp":1771815544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Web\u2010based LAS\u2010FNAME and blood biomarkers in autosomal dominant Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Christopher","family":"Gonzalez Corona","sequence":"first","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychology Rosalind Franklin University of Medicine and Science  North Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ospina Lopera","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina, Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychological and Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Vila\u2010Castelar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Harvard Medical School  Boston Massachusetts 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Gallego","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina, Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Paola","family":"Alzate Echeverri","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina, Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Serna","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina, Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience &amp; Physiology the Sahlgrenska Academy at the University of Gothenburg, Wallinsgatan  M\u00f6lndal Sweeden"},{"name":"Banner Alzheimer's Institute Phoenix Arizona USA"},{"name":"Banner Sun Health Research Institute Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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