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We evaluated three platforms\u2014single\u2010molecule array (Simoa), Ella, and Lumipulse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We measured plasma p\u2010tau217 from 113 participants underwent amyloid and tau positron emission tomography (PET; 55 AD, 36 controls, 22 non\u2010AD; classified by amyloid PET status). Diagnostic performance and PET correlations were assessed across all three platforms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      All assays distinguished amyloid\u2010positive from \u2010negative individuals with high accuracy (89%\u201395%). Simoa showed superior sensitivity, Ella the smallest gray zone in a two\u2010cutoff framework, and Lumipulse strongest tau correlation (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.770). Multiple regression revealed higher amyloid \u03b2\u2010values for Simoa\/Ella (0.420\u20130.518) and higher tau \u03b2\u2010values for Lumipulse (0.630). All platforms detected elevated p\u2010tau217 in amyloid\u2010positive individuals with substantial tau pathology despite relatively low Centiloid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>All platforms accurately detect AD with platform\u2010specific differences, which inform platform selection for clinical and research applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>Clinical Trial Registration: UMIN Clinical Trials Registry (UMIN\u2010CTR), Trial ID: UMIN000057548, Registration Date: April 8, 2025<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70294","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:53:11Z","timestamp":1773024791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of three plasma p\u2010tau217 assays to detect PET\u2010confirmed Alzheimer's pathologies"],"prefix":"10.1002","volume":"18","author":[{"given":"Sayo","family":"Matsuura","sequence":"first","affiliation":[{"name":"Advanced Neuroimaging Center Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"Collaborative Chairs Quantum Life Science Molecular Imaging Graduate School of Medicine Tohoku University  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tagai","sequence":"additional","affiliation":[{"name":"Advanced Neuroimaging Center Institute for Quantum Medical Science National Institutes 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