{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:45:42Z","timestamp":1792601142308,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sclerostin, a negative regulator of bone formation, has been involved in memory impairment in Alzheimer's disease (AD) mouse models and is increased in elderly people at risk of AD. Here, we investigated sclerostin's role across the clinical stages of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We evaluated cerebrospinal fluid (CSF) sclerostin levels in patients with dementia due to AD, mild cognitive impairment, and subjective memory complaints, biologically characterized via the amyloid\/tau\/neurodegeneration classification. Results were correlated with AD biomarkers, amyloid beta (A\u03b2) 42, phosphorylated tau (p\u2010tau), and total tau (t\u2010tau), and clinical parameters of dementia severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CSF sclerostin increased in patients with dementia due to AD and correlated negatively with A\u03b242 and positively with p\u2010tau, t\u2010tau, and dementia severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The association of CSF sclerostin with A\u03b242, tau pathology, and dementia severity in the early disease stages is of great clinical relevance for the identification of sclerostin as a promising biomarker in early AD stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70297","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:29:41Z","timestamp":1773224981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebrospinal fluid sclerostin levels in the early Alzheimer's disease stages"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-3034","authenticated-orcid":false,"given":"Manuela","family":"Dicarlo","sequence":"first","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe\u2010J) University of Bari \u201cA. Moro,\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Pignataro","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN) University of Bari \u201cA. Moro,\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Urso","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari \u201cA. Moro\u201d at \u201cPia Fondazione Card G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Zecca","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari \u201cA. Moro\u201d at \u201cPia Fondazione Card G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Dell'Abate","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari \u201cA. Moro\u201d at \u201cPia Fondazione Card G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Borlizzi","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari \u201cA. Moro\u201d at \u201cPia Fondazione Card G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gnoni","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari \u201cA. Moro\u201d at \u201cPia Fondazione Card G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giugno","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari \u201cA. Moro\u201d at \u201cPia Fondazione Card G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Oranger","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe\u2010J) University of Bari \u201cA. Moro,\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziana","family":"Colaianni","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe\u2010J) University of Bari \u201cA. 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