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The key finding was that modifiable stimulating activities showed the strongest positive association with cognition. Depressive symptoms and traumatic brain injury were the top two modifiable risk factors negatively associated with cognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These results highlight the strong potential of early, cost\u2010effective, and multifactorial dementia prevention interventions that target both modifiable risk reduction and boosting of cognitive reserve from mid\u2010life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70303","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:00:30Z","timestamp":1776769230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relative contribution of modifiable and non\u2010modifiable factors for determining cognition in mid\u2010life individuals at risk for late\u2010life Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-9215","authenticated-orcid":false,"given":"Bolin","family":"Cao","sequence":"first","affiliation":[{"name":"Trinity College Institute of Neuroscience School of Psychology Trinity College Dublin College Green  Dublin Ireland"},{"name":"Global Brain Health Institute Trinity College Dublin College Green  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Qi","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience School of Psychology Trinity College Dublin College Green  Dublin Ireland"},{"name":"Global Brain Health Institute Trinity College Dublin College Green  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Neurology Department St James's Hospital  Dublin 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