{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:31:33Z","timestamp":1787610693117,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072972"],"award-info":[{"award-number":["P30 AG072972"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG075758"],"award-info":[{"award-number":["R01 AG075758"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG077639"],"award-info":[{"award-number":["RF1 AG077639"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG031563"],"award-info":[{"award-number":["R01 AG031563"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The apolipoprotein E (ApoE) \u03b54 allele is a key genetic risk for Alzheimer's disease, but its effects may differ by heritage. We examined how ApoE4 influences hippocampal volume, episodic memory, and clinical syndrome across race and ethnicity (ethnoracial) groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 946 participants with the ApoE genotype, clinical diagnosis, and magnetic resonance imaging scans. Regression and structural equation modeling tested ApoE4's impact on cognition and whether an ethnoracial group consisting of 486 White, 234 Black\/African American, or 226 Hispanic\/Latino individuals moderated these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      ApoE4 prevalence increased with the clinical syndrome (odds ratio [OR]\u00a0=\u00a03.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). It correlated with lower hippocampal volume (\n                      <jats:italic>\u00df<\/jats:italic>\n                      \u00a0=\u00a0\u22120.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and weaker memory performance (\n                      <jats:italic>\u00df<\/jats:italic>\n                      \u00a0=\u00a0\u22120.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The indirect effect of ApoE4 via hippocampal volume was largest among White participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>ApoE4's influence on hippocampal volume, episodic memory and clinical syndrome varies by ethnoracial group, with the strongest effects among White individuals. Our findings necessitate further AD biomarker research, as standard markers may not apply universally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70304","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:55:48Z","timestamp":1773978948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of apolipoprotein E genotype with cognitive performance: findings from the University of California, Davis Alzheimer's Disease Research Center longitudinal diversity cohort"],"prefix":"10.1002","volume":"18","author":[{"given":"Eva","family":"Min","sequence":"first","affiliation":[{"name":"DePaul University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Gavett","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Sapkota","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Tomaszewski","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee\u2010Way","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Maillard","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Whitmer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"},{"name":"Department of Public Health Sciences University of California at Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2022.07.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.728"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60402-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.08.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-013-9272-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.10.751"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.08.202"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180992"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001834"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.056"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:20:3:241"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2013.07.025"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307719"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181c1ee01"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000452"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002923"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430307"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213865.09806.92"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318191c7dd"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.16.4.347"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","unstructured":"FletcherE CarmichaelO DecarliC.MRI non\u2010uniformity correction through interleaved bias estimation and B\u2010spline deformation with a template.Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference.2012;2012:106\u2010109.","DOI":"10.1109\/EMBC.2012.6345882"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","unstructured":"FletcherE SinghB HarveyD CarmichaelO DecarliC.Adaptive image segmentation for robust measurement of longitudinal brain tissue change.Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference.2012;2012:5319\u20105322.","DOI":"10.1109\/EMBC.2012.6347195"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.683426"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.05.1756"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","unstructured":"VercauterenT PennecX PerchantA AyacheN.Non\u2010parametric diffeomorphic image registration with the demons algorithm.Medical image computing and computer\u2010assisted intervention: MICCAI International Conference on Medical Image Computing and Computer\u2010Assisted Intervention.2007;10:319\u2010326.","DOI":"10.1007\/978-3-540-75759-7_39"},{"key":"e_1_2_8_32_1","article-title":"Multi\u2010atlas segmentation with joint label fusion","author":"Wang H","year":"2012","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","unstructured":"WangH YushkevichPA.Dependency prior for multi\u2010atlas label fusion.Proceedings \/IEEE International Symposium on Biomedical Imaging: from nano to macro IEEE International Symposium on Biomedical Imaging.2012;2012:892\u2010895.","DOI":"10.1109\/ISBI.2012.6235692"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.14.2.209"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.17.3.380"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.19.4.466"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v048.i02"},{"key":"e_1_2_8_38_1","volume-title":"R: A Language and Environment for Statistical Computing. 2024.9.0.375 ed","author":"Team RC","year":"2024"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr3901_4"},{"key":"e_1_2_8_40_1","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression\u2010Based Approach","author":"Hayes AF","year":"2018"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.11.2072"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000258542.58725.4c"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R075408"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.08.006"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1547-z"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4249"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14283"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12205"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0031645"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:09:08Z","timestamp":1781089748000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/dad2.70304"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70304","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70304"}}