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While appropriate use recommendations (AURs) have been established to guide clinical decision\u2010making, the proportion of individuals with cognitive impairment in real\u2010world, multiethnic populations meeting eligibility criteria remains unknown, as do potential differences in treatment\u2010related risks across ethnic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 513 cognitively impaired individuals from the Health and Aging Brain Study\u2013Health Disparities study, a multiethnic community\u2010based cohort. Eligibility for lecanemab and donanemab was determined using published AUR criteria. Counts of amyloid\u2010related imaging abnormalities were estimated based on apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 genotype and ethnicity using published incidence rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 15% of participants met eligibility criteria for lecanemab or donanemab. Black individuals had a numerically higher estimated ARIA burden, though differences were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Few individuals in this community\u2010based, multiethnic cohort met eligibility for anti\u2010amyloid therapy, highlighting limited real\u2010world applicability of current AURs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Only 15% of community\u2010based individuals with MCI or dementia met eligibility criteria for lecanemab and donanemab.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Black participants had numerically higher estimated ARIA cases, though not statistically significant.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Current AUR criteria have limited real\u2010world applicability across multiethnic populations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Broader inclusion criteria and real\u2010world safety data are needed to ensure equitable, safe implementation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70314","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:18:14Z","timestamp":1779337094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eligibility for anti\u2010amyloid treatment in a multiethnic community\u2010based study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5593-7717","authenticated-orcid":false,"given":"Lydia","family":"Trudel","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"McGill University Research Centre for Studies in Aging, Douglas Hospital Research Centre \u2010 Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"McGill University Research Centre for Studies in Aging, Douglas Hospital Research Centre \u2010 Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"McGill University Research Centre for Studies in Aging, Douglas Hospital Research Centre \u2010 Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin L.","family":"Meeker","sequence":"additional","affiliation":[{"name":"Institute for Translational Research University of North Texas Health Science Center  Fort Worth Texas USA"},{"name":"Department of Family Medicine University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith N.","family":"Braskie","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"McGill University Research Centre for Studies in Aging, Douglas Hospital Research Centre \u2010 Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vitali","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"McGill University Research Centre for Studies in Aging, Douglas Hospital Research Centre \u2010 Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et 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