{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:11:19Z","timestamp":1787670679225,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1310100"],"award-info":[{"award-number":["2017YFC1310100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AACSFD\u201022\u2010922844"],"award-info":[{"award-number":["AACSFD\u201022\u2010922844"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001728","name":"Swedish Foundation for International Cooperation in Research and Higher Education","doi-asserted-by":"publisher","award":["CH2019\u20108320"],"award-info":[{"award-number":["CH2019\u20108320"]}],"id":[{"id":"10.13039\/501100001728","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We investigated the associations of deep medullary vein (DMV) score with cognitive phenotypes and blood biomarkers for Alzheimer's disease among older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This population\u2010based cross\u2010sectional study used data from 1206 participants in the Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND\u2010China) magnetic resonance imaging (MRI) substudy; of these, plasma amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      (A\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ), total tau, neurofilament light chain, phosphorylated tau 217 (p\u2010tau217), and glial fibrillary acidic protein were measured in subsamples (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0901\u223c1133).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A higher DMV score was significantly associated with increased likelihoods of mild cognitive impairment (MCI) and amnestic MCI, and lower\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores of verbal fluency, memory, attention, executive function, and global cognition (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05); such associations were significant only in males. In the biomarker subsamples, a higher DMV score was significantly associated with a lower plasma A\n                      <jats:italic>\u03b2<\/jats:italic>\n                      42\/40 ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), but not with the other examined biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Discontinuous DMVs might be a biomarker for MCI and poor cognitive function in older men, and the role of Alzheimer's pathology deserves further exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70320","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:59:41Z","timestamp":1774925981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia\u2010free older adults: A population\u2010based study"],"prefix":"10.1002","volume":"18","author":[{"given":"Dejia","family":"Yin","sequence":"first","affiliation":[{"name":"Weifang People's Hospital, Shandong Second Medical University  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan Shandong 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