{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:57:17Z","timestamp":1785783437083,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Aducanumab is the first anti\u2010amyloid therapy used for Alzheimer's disease (AD) in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This 12\u2010month, single\u2010center, real\u2010world study enrolled 12 participants with early AD receiving aducanumab 10\u00a0mg\/kg every 4\u00a0weeks (ChiCTR2200066153). The primary outcomes were changes in Clinical Dementia Rating\u2010Sum of Boxes (CDR\u2010SB) scores at 12 months. Secondary outcomes included amyloid clearance, brain structure measures, and biomarker assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>No amyloid\u2010related imaging abnormalities occurred. The mean CDR\u2010SB score increased by 0.88 at 12 months, with cortical and hippocampal atrophy, enlarged choroid plexus, and ventricular volumes. Two autosomal dominant AD patients exhibited transient amyloid burden elevation at 6 months and subsequent reduction at 12 months, alongside increased serum glial fibrillary acidic protein (GFAP) levels. In the remaining 10 patients, the mean amyloid clearance reached \u221234.93 Centiloids, alongside decreased serum GFAP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Aducanumab showed good tolerability and favorable biological outcomes, with different responses in autosomal dominant mutation carriers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70328","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:24:14Z","timestamp":1775665454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective real\u2010world study of the efficacy and safety of aducanumab in China: Focus on early\u2010onset and autosomal dominant Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Jinwen","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Neurology and Institute of Neurology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Neurology Renji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai 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