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Its relationship with brain microstructure and cognitive impairment remains unclear. Multi\u2010component T2\u2010relaxometry is an MRI technique sensitive to myelin content, axonal degeneration, and neuroinflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 229 participants classified by p\u2010tau217 levels into p\u2010tau217\u2013 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0176), p\u2010tau217+ (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026), and intermediate (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a027) underwent neuropsychological testing and MRI. Voxel\u2010wise general linear models controlling for age, sex, education, apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      , and white matter lesions were performed for total water content (TWC), myelin water fraction (MWF), intra\u2010\/extracellular water fraction (IEWF), geometric mean of intra\u2010\/extracellular water (T2\n                      <jats:sup>IE<\/jats:sup>\n                      ), and free\/quasi\u2010free water fraction (FQFWF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The p\u2010tau217+ participants showed poorer cognition, increases in FQFWF and TWC, and reductions in IEWF and T2\n                      <jats:sup>IE<\/jats:sup>\n                      across cortical and subcortical regions and white matter tracts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>High p\u2010tau217 level associates with brain microstructure alterations and poorer cognition, supporting it as a biomarker of AD\u2010related neuropathology and the utility of T2\u2010relaxometry for detecting tissue integrity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70333","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:25:10Z","timestamp":1776655510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of plasma phosphorylated tau217 with cognitive impairment and brain microstructural alterations in Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Miguel \u00c1ngel","family":"Rivas\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Psychology 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