{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:45Z","timestamp":1785581985021,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma biomarkers and mild behavioral impairment (MBI) are associated with dementia risk, but their relationships with major depressive disorder (MDD) are understudied. This study aimed to examine associations between plasma biomarkers of Alzheimer's disease (AD) and MBI among older adults with and without MDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Older adults aged \u226565 were recruited from longitudinal studies of depression and AD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0330) in the DRIVES Project. Variables included Clinical Dementia Rating (CDR) scale, Mild Behavioral Impariment Checklist (MBI\u2010C), Neuropsychiatric Inventory Questionnaire, Area Deprivation Index, and plasma biomarkers (amyloid beta [A\u03b2] 42\/A\u03b240, phosphorylated tau (p\u2010tau) 181\/non\u2010p\u2010tau181, p\u2010tau217\/non\u2010p\u2010tau217). Logistic regression assessed associations among MDD, plasma amyloid positivity, antidepressant use, and MBI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Older adults with MDD were more likely to endorse MBI. After adjustment, A\u03b242\/A\u03b240 and p\u2010tau217\/np\u2010tau217 positivity were associated with MBI among those with MDD but not among those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Neuropsychatric symptoms (NPS) and biomarkers are AD risk factors. Early identification of MDD may reduce NPS severity, and tracking\u00a0NPS onset, duration, and frequency is crucial for AD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70337","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:06:21Z","timestamp":1777518381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between major depressive disorder, plasma biomarkers of Alzheimer's disease, and mild behavioral impairment among older adults"],"prefix":"10.1002","volume":"18","author":[{"given":"Yiqi","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Francois","family":"Trani","sequence":"additional","affiliation":[{"name":"Brown School, Washington University  St Louis Missouri USA"},{"name":"National Conservatory of Arts and Crafts, 2 rue Cont\u00e9  Paris France"},{"name":"Department of Psychology, Faculty of Humanities University of Johannesburg  Johannesburg South Africa"},{"name":"Institute of Public Health, Washington University  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkrishna K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semere","family":"Bekena","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Lenze","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine Washington University  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-3509","authenticated-orcid":false,"given":"Ganesh M.","family":"Babulal","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Washington University  St. Louis Missouri USA"},{"name":"Department of Psychology, Faculty of Humanities University of Johannesburg  Johannesburg South Africa"},{"name":"Institute of Public Health, Washington University  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20102667(21)00249\u20108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091809"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.08.026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"LucasR AlexandruH.Major depressive disorder as a risk factor of neuropsychiatric symptoms in normal and pathological aging and associations with cognitive performances. medRxiv.2022. 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