{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:51Z","timestamp":1785581991947,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201022\u2010926940"],"award-info":[{"award-number":["AARG\u201022\u2010926940"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23AG080071"],"award-info":[{"award-number":["K23AG080071"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>INTRODUCTION<\/jats:bold>\n                    : Despite expanding use of plasma biomarkers for Alzheimer's disease (AD), minimal examination has been undertaken in early\u2010onset AD (EOAD). Prior analyses assessed criterion and convergent validity of common plasma biomarkers in a well\u2010characterized sample with sporadic EOAD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS<\/jats:bold>\n                    : Plasma amyloid beta (A\u03b2) 42\/40, tau phosphorylated at threonine 231 (p\u2010tau231), glial fibrillary acidic protein (GFAP), and neurofilament light change (NfL) levels were obtained for 189 EOAD, 52 early\u2010onset non\u2010AD (EOnonAD), and 83 cognitively normal (CN) participants. Diagnostic group differences, convergence with imaging biomarkers, and the capacity to predict specific cognitive domains were investigated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS<\/jats:bold>\n                    : After controlling for cognitive status, EOAD participants exhibited more pathologic levels of A\u03b242\/40, p\u2010tau231, and GFAP relative to EOnonAD participants. However, NfL displayed the greatest sensitivity to non\u2010amnestic cognitive impairment across the sample.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DISCUSSION<\/jats:bold>\n                    : These results establish criterion and convergent validity of plasma biomarkers in sporadic EOAD and highlight complementary roles that AD\u2010specific and non\u2010specific plasma markers may play across the course of AD care.\n                  <\/jats:p>","DOI":"10.1002\/dad2.70342","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:18:12Z","timestamp":1777864692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Criterion and convergent validity of plasma biomarkers in early\u2010onset Alzheimer's disease: Initial findings from LEADS"],"prefix":"10.1002","volume":"18","author":[{"given":"Dustin 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