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Fluid\u2010based oxidative stress\u2013related biomarkers offer promising, minimally invasive platforms for early detection, with this review evaluating their diagnostic potential. Following Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines, a systematic search of PubMed, Scopus, and Google Scholar identified human studies published between 2000 and 2025 examining fluid\u2010based oxidative stress\u2013related biomarkers in individuals with AD. Elevated lipid peroxidation markers (malondialdehyde, 4\u2010hydroxynonenal, and 1\u2010palmitoyl\u20102\u2010[5\u2032\u2010oxovaleroyl]\u2010sn\u2010glycero\u20103\u2010phosphocholine) were consistently linked to AD and cognitive decline. Antioxidant enzymes (superoxide dismutase, glutathione [GSH] peroxidase, and catalase) showed reductions, while GSH and the GSH:oxidized GSH ratio emerged as robust indicators of redox imbalance in AD. Urinary 8\u2010hydroxyguanosine demonstrated compartment\u2010specific sensitivity. Altered trace elements (low selenium, iron, uric acid, and high copper) reflected systemic disruption in AD. Peripheral oxidative stress\u2013related biomarkers offer scalable, minimally invasive avenues for AD diagnosis and monitoring, supporting improved clinical decision making.<\/jats:p>","DOI":"10.1002\/dad2.70354","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:59:58Z","timestamp":1778126398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peripheral oxidative stress related biomarkers in Alzheimer's disease: A systematic review of their implications for diagnosis and disease monitoring"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5379-963X","authenticated-orcid":false,"given":"George Nkrumah","family":"Osei","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science School of Allied Health Sciences University of Cape Coast  Cape Coast 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