{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:54Z","timestamp":1785581994373,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009243","name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","doi-asserted-by":"publisher","award":["18\u2010076"],"award-info":[{"award-number":["18\u2010076"]}],"id":[{"id":"10.13039\/501100009243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Functional prognosis of early\u2010onset neurodegenerative dementia (EOD) remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The Neurodegenerative Early\u2010Onset Dementia (NEODEM) study is an ongoing prospective multicenter cohort study investigating factors associated with decline in daily activities in EOD. Detailed information on behavioral and psychological symptoms of dementia (BPSD) is collected as prognostic factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Between May 2020 and May 2023, 162 patients with EOD, including 111 patients with early\u2010onset Alzheimer's disease (AD) and 40 with frontotemporal dementia (FTD) variants, were enrolled in seven tertiary memory clinics in France. The median time from symptom onset to diagnosis was 3 years. By design, Clinical Dementia Rating (CDR) scale score was 0.5 or 1 at inclusion. Baseline level of autonomy was similar in early\u2010onset AD and FTD, but MMSE scores were lower in AD. Baseline BPSD results are presented in the manuscript.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Four\u2010year longitudinal data, available from 2027, will help clarify the impact of baseline factors on future functional status, institutionalization, morbidity, and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70361","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:59:39Z","timestamp":1779159579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and baseline findings of the NEODEM prospective cohort on early\u2010onset neurodegenerative dementia"],"prefix":"10.1002","volume":"18","author":[{"given":"Sophie","family":"Auriacombe","sequence":"first","affiliation":[{"name":"Centre M\u00e9moire Ressources Recherches, Service de Neurologie des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, P\u00f4le de Neurosciences Cliniques CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Durand","sequence":"additional","affiliation":[{"name":"Centre M\u00e9moire Ressources Recherches, Service de Neurologie des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, P\u00f4le de Neurosciences Cliniques CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Kret","sequence":"additional","affiliation":[{"name":"Service d'information M\u00e9dicale, P\u00f4le de Sant\u00e9 Publique CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Cartz\u2010Piver","sequence":"additional","affiliation":[{"name":"Centre M\u00e9moire Ressources Recherches, Service de Neurologie CHU de Limoges, Inserm, Univ. 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