{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:55:28Z","timestamp":1792108528384,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Carriers of the \u03b54 allele of the apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) gene have an increased risk for Alzheimer's disease (AD) and amyloid\u2010related imaging abnormalities (ARIAs) upon anti\u2010amyloid beta\u00a0(\u0391\u03b2) immunotherapy. Measuring apoE4 and pan\u2010apoE proteins in blood plasma for apoE4 proteotyping may offer an alternative to\n                      <jats:italic>APOE<\/jats:italic>\n                      genotyping.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We assessed apoE4 proteotyping accuracy in 479 participants of the prospective FINd DElirium RIsk factors (FINDERI) study in patients undergoing cardiac surgery and compared results to quantitative polymerase chain reaction (qPCR) genotyping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Proteotype\u2013genotype discordance occurred in 8 of 479 participants (1.67%). Five of 17 proteotype homozygotes were genotypically heterozygous. Replacing manufacturer provided cut points with custom data\u2010driven thresholds substantially improved classification performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      We confirm the reported overall high classification performance of apoE4 proteotyping but underscore the need to re\u2010evaluate the generalizability of the cut points provided with the assay kits. Misclassification of heterozygous\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers as homozygous could erroneously exclude eligible patients from anti\u2010amyloid therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70362","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:56:48Z","timestamp":1779159408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of fully automated ApoE4 proteotyping for\n                    <i>APOE<\/i>\n                    \u03b54 genotype estimation in the FINDERI cohort"],"prefix":"10.1002","volume":"18","author":[{"given":"Hans\u2010Wolfgang","family":"Klafki","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Derad","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Hohberg","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Asendorf","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esselmann","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Celano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston 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Psychosomatic Medicine and Psychotherapy University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"},{"name":"Department of Cardiovascular and Thoracic Surgery University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK)  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine AF","family":"von Arnim","sequence":"additional","affiliation":[{"name":"Department of Geriatrics University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK)  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  G\u00f6ttingen Germany"},{"name":"Department of Medical Sciences, Neurosciences and Signaling Group Institute of Biomedicine (iBiMED), University of Aveiro  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4115-0334","authenticated-orcid":false,"given":"Oliver","family":"Wirths","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center G\u00f6ttingen, Georg\u2010August\u2010University  G\u00f6ttingen 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