{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:54Z","timestamp":1785581994582,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG083189\u201001"],"award-info":[{"award-number":["1R01AG083189\u201001"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Prediction models based on administrative data may present a scalable opportunity to identify risk of cognitive impairment, but their accuracy relative to models using richer information is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We developed and validated models to identify the likelihood of mild cognitive impairment (MCI) and dementia using the Health and Retirement Study linked to Medicare data from 2000 to 2016 (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a063,740). Predictors covered most risk factors identified by the 2024 Lancet Commission. Model performance was assessed using multiple metrics, including the area under the receiver operating characteristic curve (AUC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Probit models with demographics and chronic conditions yielded high AUCs of 71.3% (MCI) and 82.1% (dementia). Adding individual level education provided the largest improvement in AUCs, whereas dual eligibility status offered smaller gains (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u00a0&lt;\u00a0\u00a00.001). Air pollution exposure, obesity, and interaction terms did not enhance prediction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Predictors in administrative data can be used to generate reasonably accurate, well calibrated models predicting likelihood of cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70363","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:45:16Z","timestamp":1778643916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of cognitive impairment using the Lancet Commission's risk factors and Medicare administrative data"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-8541","authenticated-orcid":false,"given":"Hankyung","family":"Jun","sequence":"first","affiliation":[{"name":"RAND Corporation  Santa Monica California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ye","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Becker","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yin","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-9132","authenticated-orcid":false,"given":"Soeren","family":"Mattke","sequence":"additional","affiliation":[{"name":"The USC Brain Health Observatory University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.821135"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112043"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010020\u201001648\u20109"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169267"},{"key":"e_1_2_11_6_1","volume-title":"Benefits of Seeking Early Detection of Cognitive Decline","author":"Hurd MD","year":"2024"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010017\u20100297\u2010z"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.23"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14539"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.131"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001272\u2010z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16182"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100169"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2024.100044"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000228"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475\u20106773.13386"},{"key":"e_1_2_11_18_1","first-page":"94","volume-title":"Infrastructure for Healthcare: Global Heathcare: Proceedings of the 3rd International Workshop","author":"Bansler JP","year":"2011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2021.12.016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31819c95aa"},{"key":"e_1_2_11_21_1","unstructured":"Health and Retirement Study. InUoM ed.(U01AG009740) NIoAgnN trans. Ann Arbor MI.2018."},{"key":"e_1_2_11_22_1","unstructured":"U.S. Census Bureau.American Community Survey 1\u2010year Public Use Microdata Samples.2025."},{"key":"e_1_2_11_23_1","unstructured":"Institute for Health Metrics and Evaluation (IHME).Global Burden of Disease.2025. In."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbr048"},{"key":"e_1_2_11_25_1","unstructured":"LangaKM WeirD KabetoMU SonnegaA.Langa\u2010Weir Classification of Cognitive Function (1995\u20102020).Survey Research Center Institute for Social Research University of Michigan.2023."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000945"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475\u20106773.2011.01277.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.582"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbad068"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010022"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"issue":"1","key":"e_1_2_11_32_1","first-page":"1","article-title":"Verification of forecasts expressed in terms of probability","volume":"78","author":"Gw B","year":"1950","journal-title":"Mon Weather Rev"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.11.009"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780050506"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010023\u201001849\u20100"},{"key":"e_1_2_11_36_1","unstructured":"National Institute on Aging (NIA).NIA Data LINKAGE Program (LINKAGE).2025."},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1466-7"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.11.006"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001358\u20108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3543"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:35:19Z","timestamp":1785580519000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/dad2.70363"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70363","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70363"}}