{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:48Z","timestamp":1785581988247,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["dk0207025"],"award-info":[{"award-number":["dk0207025"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["dk0207053"],"award-info":[{"award-number":["dk0207053"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH24GB1002"],"award-info":[{"award-number":["JPMH24GB1002"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 is a major genetic risk factor for dementia. We examined whether\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 genotype modified the associations between a modifiable risk factor (mRF) score and dementia in older Japanese adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study included 9605 community\u2010dwelling Japanese individuals aged \u226565 years.\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 genotype and mRF scores were assessed. Dementia was clinically diagnosed. Brain magnetic resonance imaging (MRI) measures were available in a subset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The odds ratio (OR) for dementia increased with the number of\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 alleles. A low mRF score was associated with lower ORs for prevalent dementia in non\u2010carriers and heterozygotes but not in homozygotes. On MRI, low mRF scores were associated with preserved brain structure in non\u2010carriers and heterozygotes, but not in homozygotes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Favorable risk factor profiles were associated with lower dementia risk and preserved brain structure in\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 non\u2010carriers and heterozygotes, but not in homozygotes, supporting genotype\u2010tailored prevention strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70371","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:26:57Z","timestamp":1779420417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>APOE<\/i>\n                    \u03b54, modifiable risk factors, and dementia in community\u2010based older Japanese adults"],"prefix":"10.1002","volume":"18","author":[{"given":"Masaya","family":"Kumamoto","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University  Fukuoka 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&amp; Dementia: Diagnosis, Assessment &amp; Disease 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