{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:53Z","timestamp":1785581993089,"version":"3.56.0"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG075758"],"award-info":[{"award-number":["R01AG075758"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG054548"],"award-info":[{"award-number":["RF1 AG054548"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG062429"],"award-info":[{"award-number":["P30AG062429"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19 NS 120384"],"award-info":[{"award-number":["U19 NS 120384"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG077639"],"award-info":[{"award-number":["RF1 AG077639"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072972"],"award-info":[{"award-number":["P30 AG072972"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Better cardiovascular health (CVH) is associated with better cognitive function, but limited data exist on its association with cerebrovascular disease (CVD) burden using the Life's Essential 8 (LE8) metric, particularly among Hispanic\/Latino adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>LE8 scores (range: 0 to 100) were calculated at baseline (2008 to 2011). Brain magnetic resonance imaging volumetric outcomes (2017 to 2022) included cerebral small vessel disease (cSVD) burden (infarcts, cerebral microbleeds, high white matter hyperintensity [WMH] burden, enlarged perivascular spaces), gray matter (GM), and WMH volumes. Survey\u2010weighted regression models examined associations between LE8, adjusting for demographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 2211 participants (mean age [SE]\u00a0=\u00a057.6 [8.0] years, 58.5% female), higher LE8 score was associated with reduced cSVD burden and lower odds of infarcts and WMH burden. Higher LE8 scores were associated with greater total and frontal GM and lower WMH volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Better CVH was associated with reduced CVD burden and greater GM volume in Hispanic\/Latino adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70372","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:36:27Z","timestamp":1780310187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Life's Essential 8 and cerebrovascular disease among Hispanic\/Latino adults: findings from the Hispanic Community Health Study\/Study of Latinos and Study of Latinos\u2010Investigation of Neurocognitive Aging magnetic resonance imaging cohort"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-9225","authenticated-orcid":false,"given":"Freddie","family":"M\u00e1rquez","sequence":"first","affiliation":[{"name":"Department of Neurosciences UC San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Tarraf","sequence":"additional","affiliation":[{"name":"Institute of Gerontology &amp; Department of Healthcare Sciences Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Kuwayama","sequence":"additional","affiliation":[{"name":"Department of Neurosciences UC San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Filigrana","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rekesh","sequence":"additional","affiliation":[{"name":"Department of Neurosciences UC San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda C","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Elfassy","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Davis, Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Neurosciences UC San Diego  La Jolla California 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