{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:56Z","timestamp":1785581996230,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>In Japan, confirmatory biomarker testing for Alzheimer's disease (AD) is insurance\u2010covered only when evaluating eligibility for anti\u2013amyloid\u2010\u03b2 therapies. This study aimed to identify clinical and magnetic resonance imaging (MRI) features associated with amyloid positivity in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We reviewed patients attending our secondary screening clinic between 2023 and 2024. After clinical discussions, interested patients underwent 3T MRI and either amyloid positron emission tomography (PET) or cerebrospinal fluid biomarker testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of the 200 patients, 147 proceeded to evaluation and 138 had biomarker results. The amyloid\u2010positive group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0107) was younger and had lower Mini\u2010Mental State Examination (MMSE) scores, despite similar symptom duration; younger age largely reflected early\u2010onset cases. MRI indices overlapped between the groups, except for a higher medial\u2010temporal\u2010whole\u2010brain atrophy ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Younger age and lower MMSE scores were associated with amyloid positivity. Caution regarding referral bias for early\u2010onset AD in real\u2010world settings is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70374","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T03:45:51Z","timestamp":1779507951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and MRI features associated with amyloid positivity in secondary screening for anti\u2013amyloid\u2010\u03b2 therapy"],"prefix":"10.1002","volume":"18","author":[{"given":"Kazuki","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology (TMIG)  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-0634","authenticated-orcid":false,"given":"Masanori","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department 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