{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:57Z","timestamp":1791395457800,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Lecanemab improves cerebrospinal fluid (CSF) biomarkers, but whether magnetic resonance imaging (MRI) proxies of CSF\u2013interstitial fluid (ISF) exchange improve is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This was a single\u2010center prospective pilot (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08). The ALPS index was derived from diffusion tensor image analysis along the perivascular space (DTI\u2010ALPS), and intracranial volume (ICV)\u2013normalized choroid plexus (ChP) volume was segmented with FreeSurfer Sequence Adaptive Multimodal SEGmentation (SAMSEG). Baseline changes were tested with Wilcoxon signed\u2010rank tests with Benjamini\u2013Hochberg false discovery rate (FDR) control within prespecified MRI, CSF, and cognition endpoint families.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      CSF A\u03b242 and A\u03b242\/40 increased and tau phosphorylated at threonine 181 (p\u2010tau181) decreased at 6 and 12 months (all\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0&lt;\u00a00.05); cognition showed no FDR\u2010significant change. The ALPS index showed a downward tendency (9\u2010month\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0=\u00a00.010), and ChP\/ICV increased at 6\u201312 months (all\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0=\u00a00.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The ALPS index and ChP volume may be insufficient as stand\u2010alone surrogate endpoints over 12 months. These findings suggest exploring complementary strategies targeting CSF\u2013ISF exchange and clearance pathways and warrant larger controlled longitudinal studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION INFORMATION<\/jats:title>\n                    <jats:p>Not applicable (observational study).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70375","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:41:06Z","timestamp":1783359666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal changes in DTI\u2010ALPS and choroid plexus volume relative to CSF biomarkers during lecanemab treatment in mild cognitive impairment: A pilot study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7060-151X","authenticated-orcid":false,"given":"Toshiya","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaku","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Yasu City Hospital  Yasu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Radiology Yasu City Hospital  Yasu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Radiology Yasu City Hospital  Yasu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Radiology Yasu City Hospital  Yasu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Yasu City Hospital  Yasu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Neurology Shiga Psychiatric Medical Center  Kusatsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Niimi","sequence":"additional","affiliation":[{"name":"Department of Neurology Yasu City Hospital  Yasu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Epilepsy, Movement Disorders and Physiology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenao","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/s135561771700100x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20157"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.12.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2212948"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000813\u20108"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2023.2178414"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001124\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70699"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.rev.2023\u20100175"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2024.0118"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.180372"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523001011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000201300"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70239"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987\u2010024\u201000554\u20104"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.01.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13789"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14149"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010025\u201003761\u20104"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100256"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2016.03.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(02)00569\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.09.011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103354"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.12.040"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.085"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.06.058"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053\u20108119(03)00336\u20107"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604\u2010023\u201001415\u20100"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604\u2010017\u20100617\u2010z"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001520\u2010w"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1326784"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.230009"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(24)00335\u20101"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:56:31Z","timestamp":1791392191000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/dad2.70375"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70375","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70375"}}