{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:48Z","timestamp":1785581988282,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To ensure Alzheimer's disease\u2010modifying treatments can be initiated in diverse populations, efficient pathways to obtain timely diagnoses are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This interim sub\u2010analysis of a multicenter US study included cross\u2010sectional surveys and interviews with neurologists at 12 diverse sites to assess real\u2010world lecanemab use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At survey completion, \u223c1342 patients had received lecanemab. Most referrals originated from primary care. Amyloid pathology was confirmed primarily by positron emission tomography (58%) or cerebrospinal fluid (35%), with blood\u2010based biomarkers (BBMs) increasingly used to reduce diagnostic delays. All sites performed apolipoprotein E4\n                      <jats:italic>(APOE<\/jats:italic>\n                      <jats:italic>\u03b54)<\/jats:italic>\n                      testing to inform risk\/benefit decisions. Infusions usually started within 6 months of diagnosis. Delayed\/incomplete referrals were identified as the most significant barrier in the current patient pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings demonstrate the feasibility of lecanemab integration in diverse clinical settings and highlight the importance of primary care physician engagement, optimization of referral pathways, and expanding BBM use in improving timely diagnosis, equitable access, and early treatment initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70376","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:20:59Z","timestamp":1779420059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world use of lecanemab: patient pathway findings from a US multicenter study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-4172","authenticated-orcid":false,"given":"Michael","family":"Rosenbloom","sequence":"first","affiliation":[{"name":"Memory and Brain Wellness Center University of Washington  Seattle Washington USA"},{"name":"Department of Neurology University of Washington  Seattle Washington USA"},{"name":"Alzheimer's Disease Research Center University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Adams","sequence":"additional","affiliation":[{"name":"Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Allen","sequence":"additional","affiliation":[{"name":"Roaring Fork Neurology  Basalt Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Berry","sequence":"additional","affiliation":[{"name":"Minneapolis Clinic of Neurology  Golden Valley Minnesota USA"},{"name":"Health Intelligence Lab University of Minnesota College of Science and Engineering  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Evelyn F. McKnight Brain Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Cooper","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Blvd  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Giles","sequence":"additional","affiliation":[{"name":"Memory Treatment Centers  Jacksonville Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Leahy","sequence":"additional","affiliation":[{"name":"Memorial Healthcare Institute for Neuroscience  Owosso Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Neurology Barrow Neurological Institute, St. Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sadowski","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Psychiatry, Biochemistry and Molecular Pharmacology, and the \u00a0Zachary and Elizabeth M. Fisher Alzheimer's Disease Education and Research Program NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Missouri Memory Center Citizens Memorial Hospital  Bolivar Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Neurocognitive Disorders Center, Department of Neurology The McGovern Medical School of UTHealth\u2010Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Soria","sequence":"additional","affiliation":[{"name":"The Neuron Clinic  Chula Vista California USA"},{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Weisman","sequence":"additional","affiliation":[{"name":"Abington Neurological Associates  Abington Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feride","family":"Frech","sequence":"additional","affiliation":[{"name":"Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl Rhys","family":"Jones","sequence":"additional","affiliation":[{"name":"Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000977\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010024\u201001097\u2010w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_9_6_1","unstructured":"Foo US d AdministrationDrug LEQEMBI\u00ae (lecanemab\u2010irmb) injection for intravenous or subcutaneous use prescribing information.https:\/\/www.leqembi.com\/en\/\u2010\/media\/Files\/Leqembi\/Prescribing\u2010Information.pdf>(2025)."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.11711"},{"key":"e_1_2_9_8_1","unstructured":"Delve.Delve.https:\/\/delvetool.com\/2025."},{"key":"e_1_2_9_9_1","unstructured":"US Food & Drug Administration.https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010clears\u2010first\u2010blood\u2010test\u2010used\u2010diagnosing\u2010alzheimers\u2010disease2025."},{"key":"e_1_2_9_10_1","unstructured":"Alzheimer's Association.https:\/\/www.alz.org\/news\/2025\/fda\u2010clearance\u2010blood\u2010test\u2010primary\u2010care\u2010rule\u2010out\u2010alzheimers\u2010related\u2010amyloid\u2010pathology 2025."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70752"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70535"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14184"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.13855"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003622\u2010w"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12466"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102022\u2010330540"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12787"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12647"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000200358"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.35068"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.871947"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000989\u20101"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000211489"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:34:44Z","timestamp":1785580484000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/dad2.70376"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70376","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70376"}}