{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:51Z","timestamp":1785581991993,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG053184"],"award-info":[{"award-number":["R01 AG053184"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG067021"],"award-info":[{"award-number":["R01 AG067021"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG061083"],"award-info":[{"award-number":["R01 AG061083"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study examined how apathy symptoms and awareness of those symptoms relate to resting\u2010state functional connectivity magnetic resonance imaging (rs\u2010fcMRI) across the Alzheimer's disease (AD) continuum using network segregation metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      There were eighty\u2010three participants, including cognitively unimpaired (CU;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a046), cognitively impaired (CI; mild cognitive impairment or AD dementia,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021), and mild behaviorally impaired (MBI;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016) individuals. Apathy was measured using the Apathy Evaluation Scale (AES)\u2010Self, AES\u2010Informant, and discrepancy scores (informant minus self). Models tested associations between rs\u2010fcMRI segregation and apathy. Rs\u2010fcMRI was computed using pairwise correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In CI individuals, dorsal attention network segregation related to greater apathy and reduced awareness of apathy, while in those with MBI, salience network segregation was linked to less apathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Network\u2010level connectivity disruptions differentially relate to apathy and reduced awareness across the AD continuum.<\/jats:p>\n                  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