{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:51Z","timestamp":1785581991892,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010784","name":"Banco Santander","doi-asserted-by":"publisher","award":["Ayudas a la formaci\u00f3n de j\u00f3venes investigadores SANTANDER\u2010CEU"],"award-info":[{"award-number":["Ayudas a la formaci\u00f3n de j\u00f3venes investigadores SANTANDER\u2010CEU"]}],"id":[{"id":"10.13039\/100010784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Polypharmacy is often considered harmful in older adults, yet several cardiovascular and psychiatric drugs target modifiable dementia risk factors. We examined the association between polypharmacy and progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD), overall and by sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a retrospective cohort of 4557 adults \u2265 50 years with MCI, followed for a mean of 68.7 months, polypharmacy was defined as \u2265 5 medications. Cox models adjusted for age and sex estimated hazard ratios (HRs), including sex\u2010stratified analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Polypharmacy may be associated with lower likelihood of progression to AD. Sex\u2010stratified analyses suggested differences: antidiabetics, antithrombotics, sedatives, and antidepressants were mainly associated with lower progression in women; antihypertensives in men; anxiolytics, antipsychotics, and antidementia drugs in both sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These observational findings indicate possible associations between medication use and MCI to AD progression, with potential sex\u2010specific patterns, but causality cannot be inferred. Unmeasured factors and limited covariate adjustment may contribute.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70379","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:00:18Z","timestamp":1782385218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polypharmacy is associated with lower progression from MCI to Alzheimer's disease, with sex\u2010specific patterns across drug classes"],"prefix":"10.1002","volume":"18","author":[{"given":"Mar","family":"Garc\u00eda\u2010Zamora","sequence":"first","affiliation":[{"name":"Research Group in Alzheimer Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia Spain"},{"name":"Department of Pharmacy Universidad Cardenal Herrera\u2010CEU CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4184-9855","authenticated-orcid":false,"given":"Juan","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Physics and Technological Sciences Universidad Cardenal Herrera\u2010CEU CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Esteve","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Physics and Technological Sciences Universidad Cardenal Herrera\u2010CEU CEU Universities  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Martinez\u2010Gracia","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Physics and Technological Sciences Universidad Cardenal Herrera\u2010CEU CEU Universities  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Ch\u00e1fer\u2010Peric\u00e1s","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Falc\u00f3","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Physics and Technological Sciences Universidad Cardenal Herrera\u2010CEU CEU Universities  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization (WHO).Dementia.World Health Organization;2025(cited 2024 Sep 23). 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