{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:49Z","timestamp":1791395449796,"version":"4.3.3"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Episodic memory decline impairs daily functioning in aging. This secondary analysis of data from the Age\u2010Well randomized controlled trial (RCT), we examined whether non\u2010native language training (NNLT) benefits memory and its neural correlates in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Participants from the Age\u2010Well RCT (aged \u2265 65) were assigned to an 18\u2010month NNLT (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a045), or no\u2010intervention (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a044) group. Episodic memory (California Verbal Learning Test Second Edition [CVLT\u2010II] and Logical Memory), and hippocampal and medial prefrontal cortex volumes and perfusion were assessed pre\u2010 and post\u2010intervention. Linear mixed models tested visit x group interactions. Regressions examined associations between memory and neuroimaging changes, adjusted for age, sex, education, and baseline memory performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A visit x group interaction was observed (\n                      <jats:italic>F<\/jats:italic>\n                      \u00a0=\u00a06.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01): the NNLT group maintained CVLT\u2010II delayed free recall performance, while the no\u2010intervention group declined. Within the NNLT group, changes in this score correlated positively with changes in hippocampal perfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings suggest that NNLT may help preserve hippocampus\u2010dependent long\u2010term episodic memory in aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70381","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:09:43Z","timestamp":1784801383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of an 18\u2010month non\u2010native language intervention on episodic memory and the underlying neural mechanisms in cognitively unimpaired older adults"],"prefix":"10.1002","volume":"18","author":[{"given":"Anne\u2010Laure","family":"Turpin","sequence":"first","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Ware","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"},{"name":"Universit\u00e9 de Lorraine, INTERPSY, F\u201054000  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Landeau","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"M\u00e9zenge","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asrar","family":"Lehodey","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Soussi","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Delarue","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriane","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"de la Sayette","sequence":"additional","affiliation":[{"name":"Normandie University, UNICAEN, PSL Universit\u00e9, EPHE, INSERM, U1077 CHU de Caen, GIP Cyceron, NIMH  Caen France"},{"name":"Service de Neurologie CHU de Caen  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L.","family":"Marchant","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Ch\u00e9telat","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gonneaud","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Medit\u2010Ageing Research 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