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Accounting for eGFR improved concordance of p\u2010tau181 and p\u2010tau231 with amyloid PET. Age, binarized waist\u2010to\u2010hip ratio, and amyloid status were associated with all longitudinal p\u2010tau concentrations, and eGFR associated with longitudinal p\u2010tau231.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Metabolic factors may influence the interpretation of longitudinal plasma p\u2010tau concentrations and kidney function may influence amyloid PET concordance for p\u2010tau181 and p\u2010tau231, potentially necessitating analyte\u2010specific adjustments or considerations in clinical interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70383","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:41:46Z","timestamp":1780890106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic and renal factors associated with plasma phosphorylated tau analytes used to detect Alzheimer's disease pathology"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-3417","authenticated-orcid":false,"given":"Kao Lee","family":"Yang","sequence":"first","affiliation":[{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ma","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Ennis","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Jonaitis","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Disease 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Gothenburg  M\u00f6lndal Sweden"},{"name":"Banner Alzheimer's Institute and University of Arizona  Phoenix Arizona USA"},{"name":"Banner Sun Health Research Institute  Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin  Madison Wisconsin USA"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal 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