{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:59:56Z","timestamp":1785581996114,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":78,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Regional patterns of amyloid beta (A\u03b2) deposition in Alzheimer's disease (AD) may be influenced by cerebrovascular architecture. We examined the relationship between normative arterial and venous density maps and cortical A\u03b2 burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Seventy\u2010four amyloid\u2010positive AD patients underwent amyloid positron emission tomography (PET) and magnetic resonance imaging. Regional A\u03b2 uptake was quantified; spatial associations with normative arterial (time\u2010of\u2010flight magnetic resonance angiography) and venous (susceptibility\u2010weighted imaging) density maps were assessed using correlation analyses and partial least squares (PLS) regression, controlling for early\u2010frame PET as a proxy for perfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher arterial density was associated with lower A\u03b2 uptake (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.68,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u00a00.001), independent of venous density and perfusion. PLS explained 71% of regional variance, highlighting temporo\u2010limbic regions. Subject\u2010level analyses showed heterogeneous vascular\u2013amyloid coupling, related to education and global A\u03b2 burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Arterial architecture may contribute to regional amyloid vulnerability through vascular clearance mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70390","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:16:07Z","timestamp":1781842567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the spatial covariance of cerebral vascular density and amyloid burden in Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7444-1411","authenticated-orcid":false,"given":"Lucia","family":"Argenti","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) University of Genoa  Genoa Liguria Italy"},{"name":"IRCCS Azienda Ospedaliera Metropolitana  Genoa Liguria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Cirone","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliera Metropolitana  Genoa Liguria Italy"},{"name":"Life Science Computational laboratory (LISCOMP Lab) IRCCS Ospedale\u00a0Policlinico San Martino Genoa Liguria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health 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