{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:09Z","timestamp":1791395469560,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201023\u2010IAHU\u20100011"],"award-info":[{"award-number":["ANR\u201023\u2010IAHU\u20100011"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cross\u2010sectional studies link Alzheimer's disease (AD) pathogenesis to mild behavioral impairment (MBI), but longitudinal evidence remains limited. We examined whether plasma phosphorylated tau (p\u2010tau)181 predicts progression of an MBI\u2010proxy over 2 years in pre\u2010frail and frail older adults with mild cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This is a secondary analysis of the Cognitive Function and Prevalence of Amyloid Marker in Frail Older Adults study, including 174 participants (mean age\u00a0=\u00a082.9\u00a0\u00b1\u00a05.4 years). Plasma p\u2010tau181 was analyzed both as a continuous variable and by tertiles. MBI was approximated using a Neuropsychiatric Inventory Questionnaire (NPI\u2010Q)\u2013based algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Participants in the highest tertile showed greater progression in the number of affected NPI\u2010Q\u2013derived MBI domains and overall severity compared to the lowest tertile. Continuous analyses showed a similar but non\u2010significant trend (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Amyloid and tau pathology may contribute not only to cognitive but also to behavioral impairment, supporting the hypothesis that MBI reflects underlying AD pathology, and may help identify individuals at higher risk of neuropsychiatric progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70392","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:11:48Z","timestamp":1789449108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["P\u2010tau181 is longitudinally associated with a proxy measure of mild behavioral impairment among frail older adults: Insights from COGFRAIL"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-0294","authenticated-orcid":false,"given":"Federico","family":"Bellelli","sequence":"first","affiliation":[{"name":"IHU HealthAge CHU Toulouse University Hospital  Toulouse France"},{"name":"Institut du Vieillissement G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP Inserm 1295 Toulouse University INSERM UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"IHU HealthAge CHU Toulouse University Hospital  Toulouse France"},{"name":"Institut du Vieillissement G\u00e9rontop\u00f4le de Toulouse Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP Inserm 1295 Toulouse University INSERM UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Peluso","sequence":"additional","affiliation":[{"name":"IHU HealthAge CHU Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Angioni","sequence":"additional","affiliation":[{"name":"IHU HealthAge CHU Toulouse University Hospital  Toulouse France"},{"name":"CERPOP Inserm 1295 Toulouse University INSERM UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Sourdet","sequence":"additional","affiliation":[{"name":"IHU HealthAge CHU Toulouse University Hospital  Toulouse France"},{"name":"CERPOP Inserm 1295 Toulouse University INSERM UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Soto","family":"Martin","sequence":"additional","affiliation":[{"name":"IHU HealthAge CHU Toulouse University Hospital  Toulouse 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