{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:00:05Z","timestamp":1785582005330,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000226494"],"award-info":[{"award-number":["RS\u20102023\u201000226494"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Hemispheric amyloid positron emission tomography (PET) asymmetry may capture prognostic information beyond binary amyloid status in amnestic mild cognitive impairment (aMCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We retrospectively studied 158 aMCI patients with baseline\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florbetaben PET and magnetic resonance imaging acquired within 12 months and a mean follow\u2010up of 6.89\u00a0\u00b1\u00a02.63 years. Participants were classified as amyloid beta (A\u03b2)\u2212 stable (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a067), A\u03b2\u2212 progressor (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018), A\u03b2+ stable (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a033), or A\u03b2+ progressor (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040). Vertex\u2010wise cortical standardized uptake value ratio (SUVR) asymmetry (|AI|) was analyzed using surface\u2010based general linear models adjusted for age, sex, education years, apolipoprotein E \u03b54 carrier status, global cortical SUVR, and clinical follow\u2010up duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A\u03b2\u2212 MCI progressors showed higher |AI| in the lateral orbitofrontal cortex (790 vertices, cluster\u2010wise\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0002). A\u03b2+ MCI progressors showed lower |AI| in the lingual gyrus (478 vertices, cluster\u2010wise\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0001). No cross\u2010status contrast yielded a significant cluster in the covariate\u2010adjusted model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Amyloid PET asymmetry reflects prognostic heterogeneity in aMCI, with distinct distributional patterns according to amyloid status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70394","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:08:47Z","timestamp":1782097727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional amyloid PET asymmetry and long\u2010term clinical trajectory in mild cognitive impairment"],"prefix":"10.1002","volume":"18","author":[{"given":"Yunjin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medical and Digital Engineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June Sic","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Konkuk University Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical and Digital Engineering Hanyang University  Seoul Republic of Korea"},{"name":"Department of Neurology Hanyang University Seoul Hospital  Seoul Republic of Korea"},{"name":"Department of Neurology College of Medicine Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000313"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12190"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.06.020"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132523.27540.81"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.02.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000150"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001494\u20109"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70075"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.05.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv229"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24566"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbas.2022.100048"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003662"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"1","article-title":"Seoul neuropsychological screening battery (SNSB). 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