{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:50:49Z","timestamp":1791532249414,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid\u2010related imaging abnormalities with edema (ARIA\u2010E) represent the main safety concern of anti\u2010amyloid monoclonal antibodies. Whether regional amyloid topology refines ARIA\u2010E risk in real\u2010world practice remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We analyzed 31 treatment courses in early Alzheimer's disease under European Medicines Agency labeling. Residualized occipital amyloid burden was defined as observed occipital standardized uptake value ratio (SUVR) minus occipital SUVR predicted from global composite SUVR in an expanded baseline positron emission tomography derivation sample (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a053). Associations with ARIA\u2010E and baseline plasma biomarkers were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      ARIA\u2010E occurred only in the elevated occipital amyloid group: 4\/13 treatment courses, versus 0\/18 low or comparable courses (Fisher exact\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.055). All ARIA\u2010E events involved posterior regions. The elevated pattern showed higher baseline glial fibrillary acidic protein (GFAP), phosphorylated tau (p\u2010tau)181, and p\u2010tau217 levels, whereas amyloid beta 42\/40 did not differ between groups. A GFAP + p\u2010tau217 model showed exploratory discrimination of the elevated phenotype (area under the curve: 0.76).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Disproportionate occipital amyloid burden may identify a biologically vulnerable subgroup requiring validation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70401","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:29:06Z","timestamp":1791530946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Residualized occipital amyloid burden and plasma biomarker profiles in relation to ARIA\u2010E during anti\u2010amyloid treatment"],"prefix":"10.1002","volume":"18","author":[{"given":"Federica","family":"Agosta","sequence":"first","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD), Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Neurotech Hub Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giordano","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD), Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Ghirelli","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD), Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo G.","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD), Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Rugarli","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD), Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pisano","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD), Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Coraglia","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and 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