{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:59Z","timestamp":1791395459101,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201024\u20101309896"],"award-info":[{"award-number":["AARG\u201024\u20101309896"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n Hyperostosis frontalis interna (HFI) is a relatively common incidental finding on head computed tomography (CT). We report two patients with HFI identified on amyloid\u2010beta (A\u03b2) positron emission tomography (PET)\/CT who demonstrated distinct patterns of tracer uptake within the affected calvarium.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Both patients underwent\n 18<\/jats:sup>\n F\u2010florbetaben PET\/CT imaging to assess eligibility for A\u03b2\u2010targeting therapy.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Patient 1 was an 85\u2010year\u2010old woman with amnestic mild cognitive impairment whose\n 18<\/jats:sup>\n F\u2010florbetaben PET\/CT scan revealed a Centiloid value of 59 and marked tracer uptake within the calvarium affected by HFI. Patient 2 was a 76\u2010year\u2010old woman with a Centiloid value of 82 who exhibited HFI on CT but no\n 18<\/jats:sup>\n F\u2010florbetaben uptake within the HFI region.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Off\u2010target tracer retention within the calvarium may represent a source of visual and quantitative misinterpretation in A\u03b2 and tau PET scans in patients with HFI, particularly older women. Careful visual inspection and adjustment of automated quantification masks are essential to avoid inaccurate Centiloid and standardized uptake value ratio measurements.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dad2.70402","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:35:15Z","timestamp":1782790515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Variable A\u03b2 tracer uptake in hyperostosis frontalis interna: implications for brain A\u03b2 PET\/CT interpretation"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-9533","authenticated-orcid":false,"given":"Joseph M.","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Mass General Brigham Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Mass General Brigham Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-7530","authenticated-orcid":false,"given":"Alberto","family":"Serrano\u2010Pozo","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Neurology Mass General Brigham Boston Massachusetts 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