{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:59Z","timestamp":1791395459681,"version":"4.3.3"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We investigated the association between cochlear implantation and the risk of cognitive decline in adults with hearing loss using a national population cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our cohort comprised 4106 participants who underwent cochlear implantation and matched controls with untreated hearing loss, followed over a median of 7.3 years. Propensity score matching was applied to control for confounders, and Kaplan\u2013Meier analysis was used to assess time\u2010to\u2010event outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants with cochlear implants had a significantly reduced risk of all\u2010cause dementia (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.50\u20130.74), mild cognitive impairment (HR 0.53, 95% CI 0.40\u20130.70), and memory loss (HR 0.54, 95% CI 0.45\u20130.65) compared with controls. These associations remained significant in sex\u2010stratified analyses for both male and female participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These results support early auditory intervention as a dementia prevention strategy and warrant further research with longer follow\u2010up periods across diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70409","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:54:47Z","timestamp":1784955287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cochlear implants are associated with reduced cognitive decline risk: A 20\u2010year cohort study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-8798","authenticated-orcid":false,"given":"Filippos","family":"Anagnostakis","sequence":"first","affiliation":[{"name":"Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Laboratory of AI and Biomedical Science (LABS) Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Kokkorakis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Clinical Pharmacy and Pharmacology University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Papadimopoulos","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum\u2010Medicine and Surgery University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Wen","sequence":"additional","affiliation":[{"name":"Laboratory of AI and Biomedical Science (LABS) Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Davatzikos","sequence":"additional","affiliation":[{"name":"Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"GBD 2019 Dementia Forecasting Collaborators.Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019.Lancet Public Health.2022;7(2):e105\u2010e125. doi:10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.4427"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.3509"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000001042"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0014802"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724980443000151"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2559\u201011.2011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.059"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12122"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01406\u2010X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000325"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258520"}],"container-title":["Alzheimer's &amp; 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