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The literature mostly examined series with disproportionate numbers of LATE\u2010NC over FTLD\u2010TDP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Leveraging a clinicopathological collection of FTLD\u2010TDP (\n                      <jats:italic>N\u00a0=<\/jats:italic>\n                      \u00a0148) from the University of California, San Francisco, we compared demographic, clinical, genetic, and neuropathological features of FTLD\u2010TDP, particularly FTLD\u2010TDP type A (\n                      <jats:italic>N\u00a0=<\/jats:italic>\n                      \u00a039), and LATE\u2010NC (\n                      <jats:italic>N\u00a0=<\/jats:italic>\n                      \u00a042).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      FTLD\u2010TDP type A cases were younger at onset and death, had shorter disease duration, and frequent genetic causes (\n                      <jats:italic>GRN<\/jats:italic>\n                      ,\n                      <jats:italic>C9ORF72<\/jats:italic>\n                      ) compared to LATE\u2010NC, which were mostly sporadic and older. Blinded evaluation of middle frontal gyrus (MFG) TDP\u201043 immunostaining alone proved insufficient to reliably differentiate FTLD\u2010TDP type A from LATE\u2010NC stage 3. However, factoring in all neuropathologic features, FTLD type A and LATE\u2010NC could be differentiated with\u00a0&gt;95% confidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These overall findings support distinct diagnostic entities for FTLD\u2010TDP and LATE\u2010NC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70411","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:12:53Z","timestamp":1782897173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FTLD\u2010TDP versus LATE\u2010NC: Experience of a Brain Bank specializing in FTLD\u2010TDP"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-3832","authenticated-orcid":false,"given":"D. Luke","family":"Fischer","sequence":"first","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Spina","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein 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