{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:19:00Z","timestamp":1792595940238,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG053555"],"award-info":[{"award-number":["R01AG053555"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F32AG074621"],"award-info":[{"award-number":["F32AG074621"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Upstream neuroinflammation plays an important role in Alzheimer's disease (AD) but remains poorly understood. We tested whether two distinct neuroinflammatory markers are associated with cerebrovascular burden and amyloid beta (A\u03b2), and downstream, with plasma phosphorylated tau (p\u2010tau217), medial temporal lobe (MTL) cortical and hippocampal atrophy, and memory deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Cognitively unimpaired older adults without dementia or mild cognitive impairment were recruited from a community sample (Biomarker Exploration in Aging, Cognition, and Neurodegeneration; [BEACoN];\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0126). We used structural equation modeling to test whether plasma chitinase\u20103\u2010like protein 1 (YKL\u201040) and glial fibrillary acidic protein (GFAP) contribute to distinct pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher plasma YKL\u201040 was associated with greater white matter hyperintensity (WMH), whereas higher plasma GFAP was related to increased 18F\u2010florbetapir (FBP) standardized uptake value ratio (SUVR). Higher plasma GFAP, WMH, and FBP SUVR were independently associated with increased p\u2010tau217. Plasma p\u2010tau217 was associated with reduced MTL cortical thickness and hippocampal volume. Reduced hippocampal volume was related to worse memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Future work can further investigate these neuroinflammatory pathways as potential therapeutic targets for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70415","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:00:38Z","timestamp":1786100438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Parallel neuroinflammatory pathways to cerebrovascular burden and amyloid beta in Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Batool","family":"Rizvi","sequence":"first","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"},{"name":"Department of Public Health Sciences University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna N.","family":"Adams","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Bamford","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"},{"name":"Institute for Interdisciplinary Salivary Bioscience Research University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithra","family":"Sathishkumar","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Tustison","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"},{"name":"Department of Radiology and Medical Imaging University of Virginia  Charlottesville Virginia 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California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California  Irvine California USA"},{"name":"Department of Statistics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengrui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Statistics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuritza Y.","family":"Escalante","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novelle J.","family":"Meza","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa L.","family":"Harris","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rond","family":"Malhas","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Statistics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Gertrude H. Sergievsky Center College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Neurology College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"},{"name":"Department of Neurology University of California  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"},{"name":"Institute for Interdisciplinary Salivary Bioscience Research University of California  Irvine California USA"},{"name":"Department of Neurosciences The Scripps Research Institute  La Jolla California 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