{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:54Z","timestamp":1791395454871,"version":"4.3.3"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study investigated the association between plasma myokines, including irisin, and cerebral amyloid burden across the Alzheimer's disease (AD) continuum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 100 participants were classified into four groups: amyloid\u2010negative cognitively unimpaired (A\u2212 CU), amyloid\u2010positive CU (A+ CU), A+ mild cognitive impairment (MCI), and A+ dementia of the Alzheimer's disease type (DAT). All participants underwent neuropsychological testing, brain magnetic resonance imaging, amyloid positron emission tomography, and plasma myokine assessment. Multivariable linear regression and mediation analyses were performed adjusting for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Irisin levels were significantly lower in all AD continuum groups compared to A\u2013 CU participants (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), while brain\u2010derived neurotrophic factor (BDNF) and fibroblast growth factor 21 (FGF21) showed no group differences. Higher irisin levels were associated with lower amyloid burden (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019). Mediation analysis demonstrated that amyloid burden mediated the relationship between irisin and cognitive outcomes, whereas no such effects were observed for BDNF or FGF21.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Irisin may play a key role in the muscle\u2013brain axis by linking amyloid pathology to cognitive decline in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70418","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:56:05Z","timestamp":1783997765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of plasma irisin levels with amyloid burden in the Alzheimer's disease spectrum"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-2200","authenticated-orcid":false,"given":"Young Hee","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Neurology, Hallym Sacred Heart Hospital, College of Medicine Hallym University  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Seong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Seon","family":"Eo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmi","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Beom","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine  Seoul Republic of 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