{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:53Z","timestamp":1791395453524,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We assessed plasma biomarkers for the diagnosis of early Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Subjects were divided into three groups: cognitively unimpaired (CU) (without subjective cognitive decline [SCD]) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0113), CU with SCD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0152), and mild cognitive impairment (MCI,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a045). Plasma assays for amyloid beta (A\u03b2) 40, A\u03b242, neurofilament light chain protein, glial fibrillary acidic protein, and phosphorylated tau181 levels were measured using single molecule array (Simoa) technology. Neuroinflammation and blood\u2010brain barrier (BBB) biomarkers were measured using the Corplex cytokine 10\u2010Plex kit and the angiogenesis 6\u2010Plex kit, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Biomarker levels were regressed by cognitive group, age, sex, race, and apolipoprotein E apoE \u03b54 status, yielded significant positive associations between age and numerous AD, neuroinflammation, cytokine, and BBB plasma markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Linear regression analysis, adjusted for age, sex, race, and ApoE status, revealed significant differences between cognitive groups in levels of several plasma biomarkers and associations with age and sex. Neuroinflammation and BBB dysfunction showed significant positive associations with age across different stages of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70419","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:03:46Z","timestamp":1786503826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomarkers for Alzheimer's disease to differentiate normal, SCD, and MCI subjects and their correlation with cognitive function"],"prefix":"10.1002","volume":"18","author":[{"given":"Allal","family":"Boutajangout","sequence":"first","affiliation":[{"name":"Alzheimer's Disease Research Center and Center for Cognitive Neurology  New York New York USA"},{"name":"Department of Neurology NYU Grossman School of Medicine  New York New York USA"},{"name":"Neuroscience Institute NYU Grossman School of Medicine  New York New York 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