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Previously, in a small cross\u2010sectional study, we reported higher retinal spot counts (RSCs) in preclinical amyloid PET (+) individuals screened for the Anti\u2010Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial compared to control individuals enrolled in the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) trial before drug treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Eligible volunteers had retinal scans 48\u00a0hours after consuming curcumin. Scans were processed and quantified via NeuroVision. Participants were grouped by amyloid status and treatment to assess the effect of solanezumab on RSC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>RSC did not differ significantly over time between groups and was not modified by treatment, diverging from the cross\u2010sectional retinal amyloid findings observed in A4\/LEARN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Curcumin\u2010based retinal amyloid labeling shows promise but needs standardized protocols and validation in larger cohorts to understand its relationship to amyloid PET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70422","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:34:09Z","timestamp":1783532049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationships between longitudinal retinal amyloid imaging and amyloid PET in the A4 Trial"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-0522","authenticated-orcid":false,"given":"Sonal","family":"Sukreet","sequence":"first","affiliation":[{"name":"Department of Physiology and Neuroscience, Keck School of Medicine of the University of Southern California  San Diego California USA"},{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Donohue","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ngolab","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Belsha","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Salazar","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Cohen","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veasna","family":"Tan","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute Keck School of Medicine of the University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelum T.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Alber","sequence":"additional","affiliation":[{"name":"George &amp; Anne Ryan Institute for Neuroscience  Kingston Rhode Island USA"},{"name":"University of Rhode Island  Kingston Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Johnson","sequence":"additional","affiliation":[{"name":"Neurovision Inc.  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