{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:48Z","timestamp":1791395448003,"version":"4.3.3"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Pharmacogenetics\u2010guided prescribing may reduce adverse drug reactions by 30%. European and American expert groups (Dutch Pharmacogenetics Working Group and Clinical Implementation Consortium) issue genotype\u2010based dosage recommendations, but pharmacogenetic testing is still not routinely used. Here, we assess the potential of pharmacogenetic testing to optimize pharmacotherapy in people with dementia (PwD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We genotyped variants in\n                      <jats:italic>CYP2D6<\/jats:italic>\n                      <jats:italic>, CYP2C9, CYP2C19, CYP3A4, CYP3A5<\/jats:italic>\n                      , and\n                      <jats:italic>SLCO1B1<\/jats:italic>\n                      genes and related them to individual medication data in 115 PwD from an epidemiological cohort from Northeast Germany.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The vast majority of PwD (93%) carried at least one actionable variant. Fourteen (12%) had at least one strongly actionable variant. Four of them (4%) took the drug affected and carried the strongly actionable genetic variant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Pharmacogenetic testing may contribute to improved pharmacotherapy in PwD. The potential improvements were mainly for medications commonly taken by elderly, but also for medications used to treat or associated with progression of dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70423","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:02:22Z","timestamp":1784084542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacogenetic analyses in people with dementia in Northeast Germany"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-9303","authenticated-orcid":false,"given":"Marleen Julia","family":"Meyer\u2010T\u00f6nnies","sequence":"first","affiliation":[{"name":"General Pharmacology Institute of Pharmacology Center of Drug Absorption and Transport (C_DAT) University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leefke","family":"Schwarz","sequence":"additional","affiliation":[{"name":"General Pharmacology Institute of Pharmacology Center of Drug Absorption and Transport (C_DAT) University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Wucherer","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Site Rostock\/Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Site Rostock\/Greifswald  Greifswald Germany"},{"name":"Institute for Community Medicine Section Epidemiology of Health Care and Community Health University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen Ren\u00e9","family":"Thyrian","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Site Rostock\/Greifswald  Greifswald Germany"},{"name":"Institute for Community Medicine Section Epidemiology of Health Care and Community Health University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mladen Vassilev","family":"Tzvetkov","sequence":"additional","affiliation":[{"name":"General Pharmacology Institute of Pharmacology Center of Drug Absorption and Transport (C_DAT) University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.114"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00115\u2010025\u201001839\u20101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.197"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.42"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3220.484\u2010a"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-94744-5_2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706135"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311386"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809171"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.279"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.34"},{"key":"e_1_2_8_14_1","unstructured":"Clinical Pharmacogenetics Implementation Consortium. Genes\u2010Drugs. AccessedAugust 22 2025.https:\/\/cpicpgx.org\/genes\u2010drugs\/"},{"key":"e_1_2_8_15_1","unstructured":"ClinPGx.Clinical Guideline Annotations: DPWG. Accessed August 14 2025.https:\/\/www.clinpgx.org\/guidelineAnnotations?source=dpwg"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01841\u20104"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2023.0100"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2010.0543"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160581"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106215\u201013\u201056"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010151076"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102318\u201013\u2010121"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010020\u201000862\u20106"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318\u2010023\u201000872\u20102"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2350"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010023\u201001347\u20103"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010024\u201001769\u20107"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2557"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.229"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcae200"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b6bbe3"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12325"},{"key":"e_1_2_8_33_1","unstructured":"ClinPGx.Summary annotation for CYP2D6*1 CYP2D6*1xN CYP2D6*3 CYP2D6*4 CYP2D6*5 CYP2D6*6; donepezil; Alzheimer Disease (level 3). March 25 2021. Accessed August 21 2025.https:\/\/www.clinpgx.org\/summaryAnnotation\/1184511154"},{"key":"e_1_2_8_34_1","unstructured":"FDA.Drug label ARICEPT\u00ae (donepezil hydrochloride). Published online December2018. Accessed September 25 2025.https:\/\/s3.pgkb.org\/attachment\/Donepezil_01_15_19_FDA.pdf"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2903"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2004.02743.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000311269.57716.63"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.19411"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a18691"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318160f827"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2149"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010021\u201000920\u2010y"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2526"},{"key":"e_1_2_8_44_1","unstructured":"Dutch Pharmacogenetics Working Group. Pharmacogenetic Recommendation Text. Published onlineJanuary 1 2024. Accessed August 20 2025.https:\/\/www.knmp.nl\/media\/1058"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397\u2010023\u201000315\u2010w"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12692"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.597"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010021\u201001004\u20107"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001096"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2018.0251"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2754"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106949"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3458"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.2124"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102024\u2010085852"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:55:29Z","timestamp":1791392129000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/dad2.70423"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70423","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70423"}}