{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:45Z","timestamp":1791395445415,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG077627"],"award-info":[{"award-number":["R01AG077627"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054671"],"award-info":[{"award-number":["R01AG054671"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The Mild Behavioral Impairment Checklist (MBI\u2010C) captures neuropsychiatric symptoms in individuals at risk of dementia. In this study, we examined MBI\u2010C scores in autosomal dominant Alzheimer's disease (ADAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 83 cognitively unimpaired presenilin\u20101 E280A mutation carriers and 114 non\u2010carriers with MBI\u2010C, obfjective cognition, and subjective cognitive decline (SCD) assessments. Study sub\u2010samples underwent neuroimaging to assess Alzheimer's disease (AD) pathology and neurodegeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      MBI\u2010C total scores were greater in carriers than non\u2010carriers (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>rb\u00a0<\/jats:sub>\n                      =\u00a00.19 [95% confidence interval (CI) 0.05, 0.31],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.009), driven by impulse dyscontrol symptoms. Elevated MBI\u2010C scores were associated with higher study partner\u2013reported SCD scores (\u03b2 =\u00a00.28 [95% CI 0.07, 0.050],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.008) and with greater neocortical amyloid beta (\u03b2 =\u00a00.46 [95% CI 0.17, 0.075],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.003) among carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our study reveals that mild behavioral impairment symptoms may emerge before cognitive decline in ADAD and supports the MBI\u2010C as a tool for detecting early behavioral changes linked to AD pathology and identifying at\u2010risk individuals for clinical trials and early intervention.<\/jats:p>\n                  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