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The associations of carotid\u2010femoral PWV (cfPWV) and total, structural, and load\u2010dependent PWV with dementia were estimated using Poisson regression models and Cox proportional hazards models. Dementia cases were defined by physician\u2010adjudicated review, telephone interviews, hospitalization records, and death certificates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of 4818 participants included in the study population (mean age: 75 years; 41% male, 21% Black), 1067 (22%) developed dementia over a median follow\u2010up of 9.0 years. Higher cfPWV, total PWV, structural PWV, and load\u2010dependent PWV were associated with greater dementia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Both structural and pressure\u2010related arterial stiffness mechanisms may underlie the link between PWV and dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70427","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T08:52:49Z","timestamp":1786092769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-5224","authenticated-orcid":false,"given":"Jenna","family":"Barbee","sequence":"first","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Russell","family":"Pike","sequence":"additional","affiliation":[{"name":"Optimal Aging Institute New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine McGovern Medical School, UTHealth Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education College of Education University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kucharska\u2010Newton","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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